Adhesion of Rolling Cell to Deformable Substrates in Shear Flow
| Main Author: | |
|---|---|
| Language: | English |
| Published: |
Ohio University / OhioLINK
2018
|
| Subjects: | |
| Online Access: | http://rave.ohiolink.edu/etdc/view?acc_num=ohiou153373230467728 |
| id |
ndltd-OhioLink-oai-etd.ohiolink.edu-ohiou153373230467728 |
|---|---|
| record_format |
oai_dc |
| spelling |
ndltd-OhioLink-oai-etd.ohiolink.edu-ohiou1533732304677282021-08-03T07:08:04Z Adhesion of Rolling Cell to Deformable Substrates in Shear Flow Moshaei, Mohammad Hossein Biomechanics Biomedical Engineering Biomedical Research Chemical Engineering Mechanics Mechanical Engineering Materials Science Mathematics Molecular Biology Molecular Physics Physics Biophysics Adhesive Dynamics soft substrate leukocyte Selectin Stochastic Deterministic Stability Phase Plane Cell Adhesion Cancer Drug Delivery Particle delivery Shear Flow Deformable surface leukocyte Blood Flow Red Blood cell White Blood Cell Cell rolling onto vascular endothelium under hydrodynamic blood flow is an important mechanism in many physiological and pathological processes, such as inflammatory response and tumor metastasis. The blood-borne cells are in direct contact with the most inner layer of endothelium formed by a highly compliant layer of endothelial cells. The effect of substrate stiffness on the adhesive dynamics of rolling cells is poorly understood. The goal of this thesis is to develop a modeling framework to understand the physics underlying the specific adhesion of a rolling cell to a soft bio-adhesive substrate subjected to a viscous shear flow. Of particular importance is to predict the effect of substrate stiffness on stable adhesion and rolling velocity of the cell. The developed models show a direct correlation between the state of adhesion and the substrate compliance. The results of this Thesis are anticipated to enhance our understanding of cellular arrest by endothelium and provide a quantitative basis to rational design of the nano-particles for vascular drug delivery. 2018-10-01 English text Ohio University / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=ohiou153373230467728 http://rave.ohiolink.edu/etdc/view?acc_num=ohiou153373230467728 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws. |
| collection |
NDLTD |
| language |
English |
| sources |
NDLTD |
| topic |
Biomechanics Biomedical Engineering Biomedical Research Chemical Engineering Mechanics Mechanical Engineering Materials Science Mathematics Molecular Biology Molecular Physics Physics Biophysics Adhesive Dynamics soft substrate leukocyte Selectin Stochastic Deterministic Stability Phase Plane Cell Adhesion Cancer Drug Delivery Particle delivery Shear Flow Deformable surface leukocyte Blood Flow Red Blood cell White Blood Cell |
| spellingShingle |
Biomechanics Biomedical Engineering Biomedical Research Chemical Engineering Mechanics Mechanical Engineering Materials Science Mathematics Molecular Biology Molecular Physics Physics Biophysics Adhesive Dynamics soft substrate leukocyte Selectin Stochastic Deterministic Stability Phase Plane Cell Adhesion Cancer Drug Delivery Particle delivery Shear Flow Deformable surface leukocyte Blood Flow Red Blood cell White Blood Cell Moshaei, Mohammad Hossein Adhesion of Rolling Cell to Deformable Substrates in Shear Flow |
| author |
Moshaei, Mohammad Hossein |
| author_facet |
Moshaei, Mohammad Hossein |
| author_sort |
Moshaei, Mohammad Hossein |
| title |
Adhesion of Rolling Cell to Deformable Substrates in Shear Flow |
| title_short |
Adhesion of Rolling Cell to Deformable Substrates in Shear Flow |
| title_full |
Adhesion of Rolling Cell to Deformable Substrates in Shear Flow |
| title_fullStr |
Adhesion of Rolling Cell to Deformable Substrates in Shear Flow |
| title_full_unstemmed |
Adhesion of Rolling Cell to Deformable Substrates in Shear Flow |
| title_sort |
adhesion of rolling cell to deformable substrates in shear flow |
| publisher |
Ohio University / OhioLINK |
| publishDate |
2018 |
| url |
http://rave.ohiolink.edu/etdc/view?acc_num=ohiou153373230467728 |
| work_keys_str_mv |
AT moshaeimohammadhossein adhesionofrollingcelltodeformablesubstratesinshearflow |
| _version_ |
1719454426901512192 |