Validation of Optical Coherence Tomography-Based Crystalline Lens Thickness Measurements in Children
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The Ohio State University / OhioLINK
2009
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ndltd-OhioLink-oai-etd.ohiolink.edu-osu12422482442021-08-03T05:55:49Z Validation of Optical Coherence Tomography-Based Crystalline Lens Thickness Measurements in Children Lehman, Bret M. Optics Anterior segment optical coherence tomography crystalline lens validity repeatability Visante OCT A-scan biometry <p>The purpose of this study was to evaluate the validity and repeatability of crystalline lens thickness measurements obtained by anterior segment optical coherence tomography (OCT). Optical coherence tomography utilizes infrared light and partial-coherence interferometry to produce a two-dimensional scan of the internal ocular structures in vivo. Changes in crystalline lens thickness are important to monitor for refractive error development, cataract progression, and anterior chamber alterations. Our goal was to develop an effective method of measuring the thickness of the crystalline lens with the Visante anterior segment OCT, to assess OCT repeatability, and to evaluate OCT validity as compared to A-scan ultrasonography. </p><p>Forty-seven normal children (mean age ± SD = 11.06 +/- 2.30 years) had their crystalline lens thickness measured with the Visante anterior segment OCT (Carl Zeiss Meditec, Dublin, CA) and with conventional A-scan ultrasonography (Humphrey 820). The subjects’ right corneas were anesthetized, and their right eyes were cyclopleged. Five A-scan ultrasonography measurements and three Visante OCT measurements were made per eye. Thirty-eight subjects had measurements at a second visit where three additional Visante OCT measurements were made. </p><p>The mean of the differences between the Visante OCT and A-scan ultrasonography was –0.045 mm (p = 0.017), indicating that the average measurement of crystalline lens thickness was thinner with the Visante OCT. The 95% limits of agreement were from –0.29 to 0.20 mm. When validity was assessed using only Visante OCT images that contained the corneal reflex, the mean of the differences was 0.019 mm (p = 0.11) with 95% limits of agreement from –0.091 to 0.13 mm. For the repeatability of the Visante OCT, the mean of the differences between visit one and visit two was –0.008 mm (p = 0.25) with 95% limits of agreement from -0.088 to 0.072 mm. Repeatability improved when reassessed using only images that contained the corneal reflex; the mean of the differences for these images was –0.0001 mm (p = 0.97) with 95% limits of agreement from –0.030 to 0.030 mm. In comparison to A-scan ultrasonography, a statistically significant difference was observed only when images that did not contain the corneal reflex were included in the analysis. When assessing inter-visit repeatability, a statistically significant difference was not found in either case, but the limits of agreement were narrower when repeatability was assessed using only the images containing a corneal reflex.</p><p>The Visante OCT is a non-contact instrument that is simple to use, and it provides valid crystalline lens thickness measurements with excellent repeatability. Validity and repeatability were optimized when the Visante OCT images contain the corneal reflex.</p> 2009-07-14 English text The Ohio State University / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=osu1242248244 http://rave.ohiolink.edu/etdc/view?acc_num=osu1242248244 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws. |
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NDLTD |
| language |
English |
| sources |
NDLTD |
| topic |
Optics Anterior segment optical coherence tomography crystalline lens validity repeatability Visante OCT A-scan biometry |
| spellingShingle |
Optics Anterior segment optical coherence tomography crystalline lens validity repeatability Visante OCT A-scan biometry Lehman, Bret M. Validation of Optical Coherence Tomography-Based Crystalline Lens Thickness Measurements in Children |
| author |
Lehman, Bret M. |
| author_facet |
Lehman, Bret M. |
| author_sort |
Lehman, Bret M. |
| title |
Validation of Optical Coherence Tomography-Based Crystalline Lens Thickness Measurements in Children |
| title_short |
Validation of Optical Coherence Tomography-Based Crystalline Lens Thickness Measurements in Children |
| title_full |
Validation of Optical Coherence Tomography-Based Crystalline Lens Thickness Measurements in Children |
| title_fullStr |
Validation of Optical Coherence Tomography-Based Crystalline Lens Thickness Measurements in Children |
| title_full_unstemmed |
Validation of Optical Coherence Tomography-Based Crystalline Lens Thickness Measurements in Children |
| title_sort |
validation of optical coherence tomography-based crystalline lens thickness measurements in children |
| publisher |
The Ohio State University / OhioLINK |
| publishDate |
2009 |
| url |
http://rave.ohiolink.edu/etdc/view?acc_num=osu1242248244 |
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AT lehmanbretm validationofopticalcoherencetomographybasedcrystallinelensthicknessmeasurementsinchildren |
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