Interactive Effect of the Serotonin Transporter 5-HTTLPR Genotype and Chronic Stress on Depressive Symptoms in Postmenopausal Women

Interactive Effect of the Serotonin Transporter 5-HTTLPR Genotype and Chronic Stress on Depressive Symptoms in Postmenopausal Women

Bibliographic Details
Main Author: Hantsoo, Liisa Victoria
Language:English
Published: The Ohio State University / OhioLINK 2010
Subjects:
Psychology
serotonin transporter gene
5-HTTLPR
women's health
depression
gene x environment interaction model
Online Access:http://rave.ohiolink.edu/etdc/view?acc_num=osu1266260369
id ndltd-OhioLink-oai-etd.ohiolink.edu-osu1266260369
record_format oai_dc
spelling ndltd-OhioLink-oai-etd.ohiolink.edu-osu12662603692021-08-03T05:58:32Z Interactive Effect of the Serotonin Transporter 5-HTTLPR Genotype and Chronic Stress on Depressive Symptoms in Postmenopausal Women Hantsoo, Liisa Victoria Psychology serotonin transporter gene 5-HTTLPR women's health depression gene x environment interaction model The short (s) allele of the serotonin transporter gene length polymorphism (5-HTTLPR) is associated with depression when combined with stress, in a gene by environment interaction model. This research examined the relationship between the 5-HTTLPR gene and caregiving stress on symptoms of depression in postmenopausal women. The sample included 105 female controls and 79 female dementia caregivers. Depressive symptomatology was assessed with the Center for Epidemiologic Studies Depression Scale (CES-D). Results showed that the gene by environment interaction was not significant (p=0.167) in postmenopausal women, although there was a main effect for caregiver status, such that caregivers showed higher CES-D scores than controls (p<0.001). When comparing premenopausal women to postmenopausal women, the three-way gene by environment by menopausal status interaction was not significant (p=0.711), nor was the gene by environment interaction (p=0.140). However, there was a main effect for caregiver status such that caregivers exhibited higher CES-D scores compared to controls (p=0.003). Results suggest that postmenopausal women undergoing caregiving stress exhibit higher levels of depressive symptomatology regardless of genotype, and that female caregivers are more depressed than female controls regardless of menopausal status. 2010-08-20 English text The Ohio State University / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=osu1266260369 http://rave.ohiolink.edu/etdc/view?acc_num=osu1266260369 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws.
collection NDLTD
language English
sources NDLTD
topic Psychology
serotonin transporter gene
5-HTTLPR
women's health
depression
gene x environment interaction model
spellingShingle Psychology
serotonin transporter gene
5-HTTLPR
women's health
depression
gene x environment interaction model
Hantsoo, Liisa Victoria
Interactive Effect of the Serotonin Transporter 5-HTTLPR Genotype and Chronic Stress on Depressive Symptoms in Postmenopausal Women
author Hantsoo, Liisa Victoria
author_facet Hantsoo, Liisa Victoria
author_sort Hantsoo, Liisa Victoria
title Interactive Effect of the Serotonin Transporter 5-HTTLPR Genotype and Chronic Stress on Depressive Symptoms in Postmenopausal Women
title_short Interactive Effect of the Serotonin Transporter 5-HTTLPR Genotype and Chronic Stress on Depressive Symptoms in Postmenopausal Women
title_full Interactive Effect of the Serotonin Transporter 5-HTTLPR Genotype and Chronic Stress on Depressive Symptoms in Postmenopausal Women
title_fullStr Interactive Effect of the Serotonin Transporter 5-HTTLPR Genotype and Chronic Stress on Depressive Symptoms in Postmenopausal Women
title_full_unstemmed Interactive Effect of the Serotonin Transporter 5-HTTLPR Genotype and Chronic Stress on Depressive Symptoms in Postmenopausal Women
title_sort interactive effect of the serotonin transporter 5-httlpr genotype and chronic stress on depressive symptoms in postmenopausal women
publisher The Ohio State University / OhioLINK
publishDate 2010
url http://rave.ohiolink.edu/etdc/view?acc_num=osu1266260369
work_keys_str_mv AT hantsooliisavictoria interactiveeffectoftheserotonintransporter5httlprgenotypeandchronicstressondepressivesymptomsinpostmenopausalwomen
_version_ 1719428789569585152

Similar Items