Effects of Influenza Infection on Murine Alveolar Type II Cell Function

Effects of Influenza Infection on Murine Alveolar Type II Cell Function

Bibliographic Details
Main Author: Hofer, Christian Carlisle
Language:English
Published: The Ohio State University / OhioLINK 2014
Subjects:
Biomedical Research
influenza
pneumocyte
surfactant
alveolar type II cell
Online Access:http://rave.ohiolink.edu/etdc/view?acc_num=osu1406201295
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spelling ndltd-OhioLink-oai-etd.ohiolink.edu-osu14062012952021-08-03T06:26:15Z Effects of Influenza Infection on Murine Alveolar Type II Cell Function Hofer, Christian Carlisle Biomedical Research influenza pneumocyte surfactant alveolar type II cell Influenza A virus infections result in 250,000 to 500,000 deaths annually during seasonal epidemics and pandemic outbreaks have historically killed millions. The ability of the influenza A virus genome to undergo minor changes through “antigenic drift” and major changes through “antigenic shift” poses significant challenges in developing effective annual vaccines. More importantly, these genetic alterations may yield novel strains leading to the next global pandemic. Severe respiratory disease from influenza A viruses leads to acute respiratory distress syndrome where viral replication occurs in the epithelial cells lining the alveolus. Damage to the alveolar type I (ATI) and type II (ATII) cells leads to flooding of the alveolus with edematous fluid, fibrin, erythrocytes, and other inflammatory mediators. This study investigated the effects of influenza A virus infection on those alveolar epithelial cells in a mouse model. We demonstrated that influenza infection reduces the number of ATII cells as well as dramatically alters their production of surfactant proteins. We observed a transition of ATII cells into a ATI cell phenotype by measuring the production of at ATI cell specific marker T1a/Podoplanin by ATII cells isolated from mice post infection. Continued examination and characterization of ex-vivo isolated ATII cells can provide important information into the role of ATII cells in restoring the normal epithelial lining of a damaged alveolus. Restoration of an intact respiratory epithelium is essential in the recovery from acute lung injury. 2014-11-03 English text The Ohio State University / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=osu1406201295 http://rave.ohiolink.edu/etdc/view?acc_num=osu1406201295 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws.
collection NDLTD
language English
sources NDLTD
topic Biomedical Research
influenza
pneumocyte
surfactant
alveolar type II cell
spellingShingle Biomedical Research
influenza
pneumocyte
surfactant
alveolar type II cell
Hofer, Christian Carlisle
Effects of Influenza Infection on Murine Alveolar Type II Cell Function
author Hofer, Christian Carlisle
author_facet Hofer, Christian Carlisle
author_sort Hofer, Christian Carlisle
title Effects of Influenza Infection on Murine Alveolar Type II Cell Function
title_short Effects of Influenza Infection on Murine Alveolar Type II Cell Function
title_full Effects of Influenza Infection on Murine Alveolar Type II Cell Function
title_fullStr Effects of Influenza Infection on Murine Alveolar Type II Cell Function
title_full_unstemmed Effects of Influenza Infection on Murine Alveolar Type II Cell Function
title_sort effects of influenza infection on murine alveolar type ii cell function
publisher The Ohio State University / OhioLINK
publishDate 2014
url http://rave.ohiolink.edu/etdc/view?acc_num=osu1406201295
work_keys_str_mv AT hoferchristiancarlisle effectsofinfluenzainfectiononmurinealveolartypeiicellfunction
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