The Yin and Yang of inflammation

The Yin and Yang of inflammation

Bibliographic Details
Main Author: Liu, Xiaoyu
Language:English
Published: The Ohio State University / OhioLINK 2017
Subjects:
Behavioral Sciences
Biology
Molecular Biology
Neurosciences
Immunology
Online Access:http://rave.ohiolink.edu/etdc/view?acc_num=osu1496016916912326
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spelling ndltd-OhioLink-oai-etd.ohiolink.edu-osu14960169169123262021-08-03T07:02:43Z The Yin and Yang of inflammation Liu, Xiaoyu Behavioral Sciences Biology Molecular Biology Neurosciences Immunology Inflammation is a ubiquitous form of defense which involves complex biological responses to disrupted homeostasis induced by tissue malfunction or pathogenic infections. Most of the current studies focus on the detrimental effects and adverse consequences of inflammation whereas the beneficial effects of inflammation are largely neglected and poorly exploited. Previous literature suggests that the factors that determine the trade-off of the beneficial versus detrimental effects of inflammation involve regulation of immune-to-brain signaling and diverse functions of inflammatory mediators. Therefore, this dissertation investigated these opposing aspects of inflammation. In the first half of the dissertation (chapter 2 and chapter 3) we reported the discovery of euflammation, a type of inflammation induced under muted immune-to-brain signaling. Study of euflammation demonstrates that beneficial effects of inflammation can be elicited through modulation of neuroimmune communication. In the second half of the dissertation (chapter 4 and chapter 5), we created a genetic mouse model to study the diverse functions of an inflammatory cytokine, interleukin 1. Using this model we mapped out the distribution of IL-1R1 in the brain and revealed more cell type specific IL-1R1 mediated central IL-1 effects. Taken together, these findings havepartially unraveled the complexity of inflammation and provided therapeutic values for treatment of excessive neuroinflammation. 2017-10-25 English text The Ohio State University / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=osu1496016916912326 http://rave.ohiolink.edu/etdc/view?acc_num=osu1496016916912326 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws.
collection NDLTD
language English
sources NDLTD
topic Behavioral Sciences
Biology
Molecular Biology
Neurosciences
Immunology
spellingShingle Behavioral Sciences
Biology
Molecular Biology
Neurosciences
Immunology
Liu, Xiaoyu
The Yin and Yang of inflammation
author Liu, Xiaoyu
author_facet Liu, Xiaoyu
author_sort Liu, Xiaoyu
title The Yin and Yang of inflammation
title_short The Yin and Yang of inflammation
title_full The Yin and Yang of inflammation
title_fullStr The Yin and Yang of inflammation
title_full_unstemmed The Yin and Yang of inflammation
title_sort yin and yang of inflammation
publisher The Ohio State University / OhioLINK
publishDate 2017
url http://rave.ohiolink.edu/etdc/view?acc_num=osu1496016916912326
work_keys_str_mv AT liuxiaoyu theyinandyangofinflammation
AT liuxiaoyu yinandyangofinflammation
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