Developmental changes in connectivity between the amygdala subnuclei and occipitotemporal cortex

Developmental changes in connectivity between the amygdala subnuclei and occipitotemporal cortex

Bibliographic Details
Main Author: Hansen, Heather Ann
Language:English
Published: The Ohio State University / OhioLINK 2019
Subjects:
Psychology
amygdala
subnuclei
occipitotemporal cortex
structural connectivity
DWI
tractography
development
Online Access:http://rave.ohiolink.edu/etdc/view?acc_num=osu1556631333522481
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spelling ndltd-OhioLink-oai-etd.ohiolink.edu-osu15566313335224812021-08-03T07:10:59Z Developmental changes in connectivity between the amygdala subnuclei and occipitotemporal cortex Hansen, Heather Ann Psychology amygdala subnuclei occipitotemporal cortex structural connectivity DWI tractography development The amygdala, a subcortical structure known for social and emotional processing, can be subdivided into multiple nuclei with unique functions and connectivity patterns. Tracer studies in adult macaques have shown that the lateral and basal amygdala subnuclei decrease in connectivity to visual cortical areas moving from anterior to posterior, and that infants have similar adult-like projections plus additional connections that are refined with development. Can we delineate the connectivity between the amygdala subnuclei and occipitotemporal cortex in humans, and will it show similar developmental differences as macaques? If so, what functional regions may be contributing to this pattern of connectivity? To address these questions, we anatomically defined the lateral and basal amygdala subnuclei in 20 adult subjects, 27 kids (aged 7-8), and 15 neonates. We then defined the occipitotemporal region in each individual’s native anatomy, and split this entire region into five equal sections from anterior to posterior. We also defined visual functional parcellations in the occipitotemporal cortex (e.g., FFA, PPA) and anatomically defined primary visual cortex (i.e., V1). Using Diffusion Weighted Imaging data, we ran probabilistic tractography with FSL between the amygdala subnuclei as seeds and the occipitotemporal cortical parcellations as targets. Results showed that like macaques, the mean connectivity across subjects to the occipitotemporal cortex significantly decreased on a gradient from anterior to posterior, and that connectivity in kids and neonates was adult-like but became more refined across development. Further, refinement of connectivity to mid and posterior occipitotemporal cortex was largely driven by anterior PPA, LO, and V1, with connectivity to higher order visual areas increasing with age. The functional maturation of these regions may contribute to the continued refinement of these connections, in line with Interactive Specialization hypotheses of brain development. 2019 English text The Ohio State University / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=osu1556631333522481 http://rave.ohiolink.edu/etdc/view?acc_num=osu1556631333522481 unrestricted This thesis or dissertation is protected by copyright: some rights reserved. It is licensed for use under a Creative Commons license. Specific terms and permissions are available from this document's record in the OhioLINK ETD Center.
collection NDLTD
language English
sources NDLTD
topic Psychology
amygdala
subnuclei
occipitotemporal cortex
structural connectivity
DWI
tractography
development
spellingShingle Psychology
amygdala
subnuclei
occipitotemporal cortex
structural connectivity
DWI
tractography
development
Hansen, Heather Ann
Developmental changes in connectivity between the amygdala subnuclei and occipitotemporal cortex
author Hansen, Heather Ann
author_facet Hansen, Heather Ann
author_sort Hansen, Heather Ann
title Developmental changes in connectivity between the amygdala subnuclei and occipitotemporal cortex
title_short Developmental changes in connectivity between the amygdala subnuclei and occipitotemporal cortex
title_full Developmental changes in connectivity between the amygdala subnuclei and occipitotemporal cortex
title_fullStr Developmental changes in connectivity between the amygdala subnuclei and occipitotemporal cortex
title_full_unstemmed Developmental changes in connectivity between the amygdala subnuclei and occipitotemporal cortex
title_sort developmental changes in connectivity between the amygdala subnuclei and occipitotemporal cortex
publisher The Ohio State University / OhioLINK
publishDate 2019
url http://rave.ohiolink.edu/etdc/view?acc_num=osu1556631333522481
work_keys_str_mv AT hansenheatherann developmentalchangesinconnectivitybetweentheamygdalasubnucleiandoccipitotemporalcortex
_version_ 1719455761008951296

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