Crosstalk between the Jak-Stat and Wingless pathways is mediated by Mad in Drosophila melanogaster larval hematopoiesis.
| Main Author: | |
|---|---|
| Language: | English |
| Published: |
Ohio University Art and Sciences Honors Theses / OhioLINK
2013
|
| Subjects: | |
| Online Access: | http://rave.ohiolink.edu/etdc/view?acc_num=ouashonors1367508013 |
| id |
ndltd-OhioLink-oai-etd.ohiolink.edu-ouashonors1367508013 |
|---|---|
| record_format |
oai_dc |
| spelling |
ndltd-OhioLink-oai-etd.ohiolink.edu-ouashonors13675080132021-08-03T05:23:05Z Crosstalk between the Jak-Stat and Wingless pathways is mediated by Mad in Drosophila melanogaster larval hematopoiesis. Rush, Craig Michael Cellular Biology Genetics Molecular Biology Biology Wnt Wg Wingless Wingless Pathway Signal Transduction Crosstalk Mad SMAD Jak-Stat Jak-Stat Pathway Hematopoiesis Drosophila melanogaster Signal transduction pathway larval hematopoiesis hemocyte Cancer is a leading cause of death in the United States. Cancer arises due to the accumulation of multiple mutations. These mutations can occur in signaling transduction pathways that then impact other pathways through crosstalk. Crosstalk between pathways is an expanding area of research as it demonstrates how one mutation can affect other systems downstream. The identification of proteins that mediate crosstalk also allows for the potential development of therapeutic drugs to interrupt the crosstalk, potentially nullifying the initial mutation.Two pathways that are involved in many types of human cancers are the Jak-Stat and Wnt (Wingless, Wg) pathways. These two pathways are also involved in the development of a leukemia-like disease seen in Hop[Tum-l] mutants in Drosophila. Here I show that these two pathways crosstalk in vivo, mediated by the protein Mad. I show that this crosstalk is important to the proliferation of larval hemocytes and their differentiation into a specialized cell type, the lamellocyte. I propose and test a model whereby the Jak-Stat pathway activates proliferation and differentiation while the Wnt pathway activates proliferation and inhibits differentiation. I examine if differentiation in an overactive Jak-Stat mutant, Hop[Tum-l], requires activity of Mad. Additionally, I examine if Mad inhibits Wg pathway activity in hematopoiesis. From my results, I propose a system where the protein Mad mediates the crosstalk between the Jak-Stat and Wnt pathways by inhibiting the Wnt pathway. 2013 English text Ohio University Art and Sciences Honors Theses / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=ouashonors1367508013 http://rave.ohiolink.edu/etdc/view?acc_num=ouashonors1367508013 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws. |
| collection |
NDLTD |
| language |
English |
| sources |
NDLTD |
| topic |
Cellular Biology Genetics Molecular Biology Biology Wnt Wg Wingless Wingless Pathway Signal Transduction Crosstalk Mad SMAD Jak-Stat Jak-Stat Pathway Hematopoiesis Drosophila melanogaster Signal transduction pathway larval hematopoiesis hemocyte |
| spellingShingle |
Cellular Biology Genetics Molecular Biology Biology Wnt Wg Wingless Wingless Pathway Signal Transduction Crosstalk Mad SMAD Jak-Stat Jak-Stat Pathway Hematopoiesis Drosophila melanogaster Signal transduction pathway larval hematopoiesis hemocyte Rush, Craig Michael Crosstalk between the Jak-Stat and Wingless pathways is mediated by Mad in Drosophila melanogaster larval hematopoiesis. |
| author |
Rush, Craig Michael |
| author_facet |
Rush, Craig Michael |
| author_sort |
Rush, Craig Michael |
| title |
Crosstalk between the Jak-Stat and Wingless pathways is mediated by Mad in Drosophila melanogaster larval hematopoiesis. |
| title_short |
Crosstalk between the Jak-Stat and Wingless pathways is mediated by Mad in Drosophila melanogaster larval hematopoiesis. |
| title_full |
Crosstalk between the Jak-Stat and Wingless pathways is mediated by Mad in Drosophila melanogaster larval hematopoiesis. |
| title_fullStr |
Crosstalk between the Jak-Stat and Wingless pathways is mediated by Mad in Drosophila melanogaster larval hematopoiesis. |
| title_full_unstemmed |
Crosstalk between the Jak-Stat and Wingless pathways is mediated by Mad in Drosophila melanogaster larval hematopoiesis. |
| title_sort |
crosstalk between the jak-stat and wingless pathways is mediated by mad in drosophila melanogaster larval hematopoiesis. |
| publisher |
Ohio University Art and Sciences Honors Theses / OhioLINK |
| publishDate |
2013 |
| url |
http://rave.ohiolink.edu/etdc/view?acc_num=ouashonors1367508013 |
| work_keys_str_mv |
AT rushcraigmichael crosstalkbetweenthejakstatandwinglesspathwaysismediatedbymadindrosophilamelanogasterlarvalhematopoiesis |
| _version_ |
1719419300176986112 |