A Computational Model of Neurofilament Kinetics Relating Axonal Caliber Growth and the Neurofilament Slowing Phenomenon

Bibliographic Details
Main Author:	Friedman, Anika J.
Language:	English
Published:	Ohio University Honors Tutorial College / OhioLINK 2019
Subjects:	Biophysics Biology Neurosciences Physics neurofilaments neurofilament transport neurofilament kinetics computational modeling biophysics axonal caliber growth
Online Access:	http://rave.ohiolink.edu/etdc/view?acc_num=ouhonors1556283731141422

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spelling	ndltd-OhioLink-oai-etd.ohiolink.edu-ouhonors15562837311414222021-08-03T07:10:49Z A Computational Model of Neurofilament Kinetics Relating Axonal Caliber Growth and the Neurofilament Slowing Phenomenon Friedman, Anika J. Biophysics Biology Neurosciences Physics neurofilaments neurofilament transport neurofilament kinetics computational modeling biophysics axonal caliber growth Neurofilaments (NFs) are a major component of the cytoskeleton of the axons of neurons and they contribute to the establishment of the axon’s cross-sectional area. NFs are also a cargo of slow transport along microtubules (MTs) thus relating NF movement with axon caliber. Studies in rats have reported that the NF transport velocity slows significantly and continuously prior to and after sexual maturity (approximately 4 to 5 weeks in rats) while NF slowing continues past 12 weeks of age. Direct experimentation has given insight into the kinetics of NF transport, but the exact mechanism by which NFs transport is regulated leading to the reported slowing remains unknown. Computational modeling aids in the exploration of possible mechanisms of regulation of NF transport and evaluation of possible contributions of NF transport velocity to changes in axon diameter. Our hypothesis is that growth of the axonal cross-sectional area requires a combination of change of NF kinetics, associated with a change of the densities of NFs and MTs, and an increase in their abundance through increased NF assembly rate in the cell body. This research aims to develop models which would provide new insights into the mechanism of axon growth in normal development, which could help researchers understand the mechanisms of abnormal axon swelling in specific neurodegenerative diseases. The primary conclusions of this research were that the velocity obtained from radio-labeled NF pulse experiments may not be representative of the average velocity and therefore the reported NF slowing on a timescale of days and weeks may have been mainly due to an incorrect interpretation of the outcomes of radio-pulse-labeling experiments. 2019 English text Ohio University Honors Tutorial College / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=ouhonors1556283731141422 http://rave.ohiolink.edu/etdc/view?acc_num=ouhonors1556283731141422 restricted--full text unavailable until 2022-01-28 This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws.
collection	NDLTD
language	English
sources	NDLTD
topic	Biophysics Biology Neurosciences Physics neurofilaments neurofilament transport neurofilament kinetics computational modeling biophysics axonal caliber growth
spellingShingle	Biophysics Biology Neurosciences Physics neurofilaments neurofilament transport neurofilament kinetics computational modeling biophysics axonal caliber growth Friedman, Anika J. A Computational Model of Neurofilament Kinetics Relating Axonal Caliber Growth and the Neurofilament Slowing Phenomenon
author	Friedman, Anika J.
author_facet	Friedman, Anika J.
author_sort	Friedman, Anika J.
title	A Computational Model of Neurofilament Kinetics Relating Axonal Caliber Growth and the Neurofilament Slowing Phenomenon
title_short	A Computational Model of Neurofilament Kinetics Relating Axonal Caliber Growth and the Neurofilament Slowing Phenomenon
title_full	A Computational Model of Neurofilament Kinetics Relating Axonal Caliber Growth and the Neurofilament Slowing Phenomenon
title_fullStr	A Computational Model of Neurofilament Kinetics Relating Axonal Caliber Growth and the Neurofilament Slowing Phenomenon
title_full_unstemmed	A Computational Model of Neurofilament Kinetics Relating Axonal Caliber Growth and the Neurofilament Slowing Phenomenon
title_sort	computational model of neurofilament kinetics relating axonal caliber growth and the neurofilament slowing phenomenon
publisher	Ohio University Honors Tutorial College / OhioLINK
publishDate	2019
url	http://rave.ohiolink.edu/etdc/view?acc_num=ouhonors1556283731141422
work_keys_str_mv	AT friedmananikaj acomputationalmodelofneurofilamentkineticsrelatingaxonalcalibergrowthandtheneurofilamentslowingphenomenon AT friedmananikaj computationalmodelofneurofilamentkineticsrelatingaxonalcalibergrowthandtheneurofilamentslowingphenomenon
_version_	1719455894716022784

A Computational Model of Neurofilament Kinetics Relating Axonal Caliber Growth and the Neurofilament Slowing Phenomenon

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