Cortical Bone Mechanics Technology (CBMT) and Dual X-Ray Absorptiometry (DXA) Sensitivity to Bone Collagen Degradation in Human Ulna Bone

Cortical Bone Mechanics Technology (CBMT) and Dual X-Ray Absorptiometry (DXA) Sensitivity to Bone Collagen Degradation in Human Ulna Bone

Bibliographic Details
Main Author: Warnock, Sarah M.
Language:English
Published: Ohio University Honors Tutorial College / OhioLINK 2019
Subjects:
Biomechanics
Biomedical Research
Anatomy and Physiology
Technology
Bone strength
flexural rigidity
bone fragility
bone mineral density
bone mechanics
ulna
osteoporosis
biomechanics
technology
fracture risk
Online Access:http://rave.ohiolink.edu/etdc/view?acc_num=ouhonors1556305540256918
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spelling ndltd-OhioLink-oai-etd.ohiolink.edu-ouhonors15563055402569182021-08-03T07:10:50Z Cortical Bone Mechanics Technology (CBMT) and Dual X-Ray Absorptiometry (DXA) Sensitivity to Bone Collagen Degradation in Human Ulna Bone Warnock, Sarah M. Biomechanics Biomedical Research Anatomy and Physiology Technology Bone strength flexural rigidity bone fragility bone mineral density bone mechanics ulna osteoporosis biomechanics technology fracture risk Bone is often regarded as a mostly inorganic tissue. Osteoporosis, a skeletal metabolic disorder characterized by increased bone fragility and fracture risk, is currently diagnosed by Dual X-Ray Absorptiometry (DXA) scan. However, DXA scanning is a poor predictor of fracture risk and bone quality, as it only assesses the mineral content of bone. Recent research increasingly suggests that other nonmineral parameters contribute to bone strength, such as size, geometry, and organic collagen. As a result, it is imperative to find a better diagnostic tool that more accurately encapsulates these other factors. One potential solution is Cortical Bone Mechanics Technology (CBMT), a novel technology being developed at Ohio University that uses noninvasive, radiation-free three point mechanical loading test to assess bone flexural rigidity (EI). Because CBMT is a mechanical test, it is believed to better detect changes in nonmineral factors. To assess this, compromising of the organic collagen matrix was induced using potassium hydroxide (KOH), which does not affect bone mineral. Paired cadaveric human forearms (n=16) were treated with either saline (n=8) or KOH (n=8). No statistically significant difference was present between the right and left T-scores of excised ulnas prior to chemical incubation (p= 0.40). No statistically significant difference between the KOH and saline cohorts prior to chemical incubation (p=0.27). Arms were assessed with DXA and CBMT both before and after treatment. Saline immersion did not reduce EIQMT (+0.9±1.2%, p= 0.76) or EICBMT (-0.6±2.3%, p=0.40). By contrast, KOH immersion reduced both EIQMT (-27.2±3.2%, p<0.0001) and EICBMT (-20.6±6.1%, p<0.01), with no difference between the magnitudes of these effects (p=0.21). Ulna BMD at the 1/3 region was not reduced by either saline (-1.4±0.9%, p = 0.09) or KOH (0.2±0.8%, p=0.76). Thus, CBMT detected collagen-mediated effects of KOH on the bending stiffness of whole cadaveric human ulna bones, and DXA did not. Compared to endosteal immersion, periosteal immersion accelerated treatment effects by ~1000%. 2019 English text Ohio University Honors Tutorial College / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=ouhonors1556305540256918 http://rave.ohiolink.edu/etdc/view?acc_num=ouhonors1556305540256918 restricted--full text unavailable until 2022-01-28 This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws.
collection NDLTD
language English
sources NDLTD
topic Biomechanics
Biomedical Research
Anatomy and Physiology
Technology
Bone strength
flexural rigidity
bone fragility
bone mineral density
bone mechanics
ulna
osteoporosis
biomechanics
technology
fracture risk
spellingShingle Biomechanics
Biomedical Research
Anatomy and Physiology
Technology
Bone strength
flexural rigidity
bone fragility
bone mineral density
bone mechanics
ulna
osteoporosis
biomechanics
technology
fracture risk
Warnock, Sarah M.
Cortical Bone Mechanics Technology (CBMT) and Dual X-Ray Absorptiometry (DXA) Sensitivity to Bone Collagen Degradation in Human Ulna Bone
author Warnock, Sarah M.
author_facet Warnock, Sarah M.
author_sort Warnock, Sarah M.
title Cortical Bone Mechanics Technology (CBMT) and Dual X-Ray Absorptiometry (DXA) Sensitivity to Bone Collagen Degradation in Human Ulna Bone
title_short Cortical Bone Mechanics Technology (CBMT) and Dual X-Ray Absorptiometry (DXA) Sensitivity to Bone Collagen Degradation in Human Ulna Bone
title_full Cortical Bone Mechanics Technology (CBMT) and Dual X-Ray Absorptiometry (DXA) Sensitivity to Bone Collagen Degradation in Human Ulna Bone
title_fullStr Cortical Bone Mechanics Technology (CBMT) and Dual X-Ray Absorptiometry (DXA) Sensitivity to Bone Collagen Degradation in Human Ulna Bone
title_full_unstemmed Cortical Bone Mechanics Technology (CBMT) and Dual X-Ray Absorptiometry (DXA) Sensitivity to Bone Collagen Degradation in Human Ulna Bone
title_sort cortical bone mechanics technology (cbmt) and dual x-ray absorptiometry (dxa) sensitivity to bone collagen degradation in human ulna bone
publisher Ohio University Honors Tutorial College / OhioLINK
publishDate 2019
url http://rave.ohiolink.edu/etdc/view?acc_num=ouhonors1556305540256918
work_keys_str_mv AT warnocksarahm corticalbonemechanicstechnologycbmtanddualxrayabsorptiometrydxasensitivitytobonecollagendegradationinhumanulnabone
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