The Induction of Traumatic Brain Injury by Blood Brain Barrier Disruption
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University of Toledo / OhioLINK
2011
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| Online Access: | http://rave.ohiolink.edu/etdc/view?acc_num=toledo1302125115 |
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ndltd-OhioLink-oai-etd.ohiolink.edu-toledo13021251152021-08-03T06:07:48Z The Induction of Traumatic Brain Injury by Blood Brain Barrier Disruption Skopin, Mark D. Biomedical Engineering Medicine Neurosciences Blood-brain barrier memory and learning Barnes circular maze traumatic brain injury hyperosmotic solution controlled cortical impact Animal models of traumatic brain injury (TBI) are utilized for the study of underlying mechanisms and for the development of potential therapeutics. Traditional TBI models apply concussive forces to the cranium or provide a direct injury to neuronal tissue to model penetrating head wounds. The observation of mild to moderate TBI symptoms in personnel exposed to blast waves has led to the hypothesis that the disruption of the blood-brain barrier (BBB) can cause the symptoms commonly associated with TBI. Using intracarotid injection of hyperosmotic fluid, we assessed the histological and behavioral consequences of a transient disruption of the BBB and compared the results to the classical controlled-cortical impact (CCI) model of penetrating head injuries in rats. Our results demonstrate that the disruption of the BBB causes similar deficits in spatial memory as measured by the Barnes maze compared to other classical TBI models. Furthermore, a computational model was developed to investigate how different types of neural injuries affect a biological network capable of neurogenesis. These findings suggest that a disruption of the BBB can contribute to the neuronal dysfunction associated with brain injury and novel treatments that prevent plasma extravasation during BBB disruption could have therapeutic benefits. 2011-06-10 English text University of Toledo / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=toledo1302125115 http://rave.ohiolink.edu/etdc/view?acc_num=toledo1302125115 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws. |
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NDLTD |
| language |
English |
| sources |
NDLTD |
| topic |
Biomedical Engineering Medicine Neurosciences Blood-brain barrier memory and learning Barnes circular maze traumatic brain injury hyperosmotic solution controlled cortical impact |
| spellingShingle |
Biomedical Engineering Medicine Neurosciences Blood-brain barrier memory and learning Barnes circular maze traumatic brain injury hyperosmotic solution controlled cortical impact Skopin, Mark D. The Induction of Traumatic Brain Injury by Blood Brain Barrier Disruption |
| author |
Skopin, Mark D. |
| author_facet |
Skopin, Mark D. |
| author_sort |
Skopin, Mark D. |
| title |
The Induction of Traumatic Brain Injury by Blood Brain Barrier Disruption |
| title_short |
The Induction of Traumatic Brain Injury by Blood Brain Barrier Disruption |
| title_full |
The Induction of Traumatic Brain Injury by Blood Brain Barrier Disruption |
| title_fullStr |
The Induction of Traumatic Brain Injury by Blood Brain Barrier Disruption |
| title_full_unstemmed |
The Induction of Traumatic Brain Injury by Blood Brain Barrier Disruption |
| title_sort |
induction of traumatic brain injury by blood brain barrier disruption |
| publisher |
University of Toledo / OhioLINK |
| publishDate |
2011 |
| url |
http://rave.ohiolink.edu/etdc/view?acc_num=toledo1302125115 |
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AT skopinmarkd theinductionoftraumaticbraininjurybybloodbrainbarrierdisruption AT skopinmarkd inductionoftraumaticbraininjurybybloodbrainbarrierdisruption |
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