Non-Invasive Biomarkers of Eosinophilic Esophagitis: Blood Eosinophil Level, Eosinophil-Derived Neurotoxin, and Eotaxin-3

Non-Invasive Biomarkers of Eosinophilic Esophagitis: Blood Eosinophil Level, Eosinophil-Derived Neurotoxin, and Eotaxin-3

Bibliographic Details
Main Author: Konikoff, Michael R.
Language:English
Published: University of Cincinnati / OhioLINK 2006
Subjects:
eosinophilic esophagitis
biomarker
eosinophil
eosinophil-derived neurotoxin
eotaxin-3
Online Access:http://rave.ohiolink.edu/etdc/view?acc_num=ucin1148043525
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spelling ndltd-OhioLink-oai-etd.ohiolink.edu-ucin11480435252021-08-03T06:11:11Z Non-Invasive Biomarkers of Eosinophilic Esophagitis: Blood Eosinophil Level, Eosinophil-Derived Neurotoxin, and Eotaxin-3 Konikoff, Michael R. eosinophilic esophagitis biomarker eosinophil eosinophil-derived neurotoxin eotaxin-3 Eosinophilic esophagitis (EE) is an increasingly recognized disorder characterized by eosinophilic inflammation of the esophageal mucosa, and typically requires serial, invasive endoscopic biopsies to document the characteristic histologic features of the disorder. The aim of this study was to identify non-invasive biomarkers that correlated with disease activity and response to treatment as measured by esophageal eosinophilia. METHODS: A prospective, cross-sectional analysis was performed on 47 pediatric patients undergoing endoscopic evaluation of possible EE. Blood samples were collected for measurement of peripheral blood absolute eosinophil count (AEC) and levels of eosinophil-derived neurotoxin (EDN), eotaxin-1, -2, and -3, and interleukin-5. Stool samples were collected for measurement of EDN. Biomarker levels were correlated with esophageal eosinophil density, and differences in biomarker levels based on disease activity and treatment were determined. RESULTS: AEC, plasma EDN, and eotaxin-3 levels significantly correlated with esophageal eosinophil density (AEC r=0.56, P<0.0001; EDN r=0.54, P<0.0001; eotaxin-3 r=0.32, P=0.04), and were increased in patients with active EE versus controls (AEC 440 vs 140 eosinophils/µL, P<0.05; EDN 50.3 vs 31.1 ng/mL, P<0.01; eotaxin-3 37.7 vs 11.5 pg/mL, P<0.01). Cutoffs were established to maximize the sensitivity, specificity, and predictive values of these biomarkers alone and in combination. Eotaxin-1 and -2, interleukin-5, and fecal EDN levels did not correlate with esophageal eosinophil density, and were not increased in active EE versus controls or those with inactive EE. CONCLUSIONS: These data demonstrate that blood levels of AEC, EDN, and eotaxin-3 may have value as non-invasive biomarkers for monitoring EE. 2006-07-13 English text University of Cincinnati / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=ucin1148043525 http://rave.ohiolink.edu/etdc/view?acc_num=ucin1148043525 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws.
collection NDLTD
language English
sources NDLTD
topic eosinophilic esophagitis
biomarker
eosinophil
eosinophil-derived neurotoxin
eotaxin-3
spellingShingle eosinophilic esophagitis
biomarker
eosinophil
eosinophil-derived neurotoxin
eotaxin-3
Konikoff, Michael R.
Non-Invasive Biomarkers of Eosinophilic Esophagitis: Blood Eosinophil Level, Eosinophil-Derived Neurotoxin, and Eotaxin-3
author Konikoff, Michael R.
author_facet Konikoff, Michael R.
author_sort Konikoff, Michael R.
title Non-Invasive Biomarkers of Eosinophilic Esophagitis: Blood Eosinophil Level, Eosinophil-Derived Neurotoxin, and Eotaxin-3
title_short Non-Invasive Biomarkers of Eosinophilic Esophagitis: Blood Eosinophil Level, Eosinophil-Derived Neurotoxin, and Eotaxin-3
title_full Non-Invasive Biomarkers of Eosinophilic Esophagitis: Blood Eosinophil Level, Eosinophil-Derived Neurotoxin, and Eotaxin-3
title_fullStr Non-Invasive Biomarkers of Eosinophilic Esophagitis: Blood Eosinophil Level, Eosinophil-Derived Neurotoxin, and Eotaxin-3
title_full_unstemmed Non-Invasive Biomarkers of Eosinophilic Esophagitis: Blood Eosinophil Level, Eosinophil-Derived Neurotoxin, and Eotaxin-3
title_sort non-invasive biomarkers of eosinophilic esophagitis: blood eosinophil level, eosinophil-derived neurotoxin, and eotaxin-3
publisher University of Cincinnati / OhioLINK
publishDate 2006
url http://rave.ohiolink.edu/etdc/view?acc_num=ucin1148043525
work_keys_str_mv AT konikoffmichaelr noninvasivebiomarkersofeosinophilicesophagitisbloodeosinophilleveleosinophilderivedneurotoxinandeotaxin3
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