Association of Maternal Adipokines with Infant Anthropometry in Obese, Pregnant Women
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University of Cincinnati / OhioLINK
2011
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| Online Access: | http://rave.ohiolink.edu/etdc/view?acc_num=ucin1307125407 |
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ndltd-OhioLink-oai-etd.ohiolink.edu-ucin13071254072021-08-03T06:14:49Z Association of Maternal Adipokines with Infant Anthropometry in Obese, Pregnant Women Gardner, Alison Nutrition pregnancy insulin resistance adipokines macrosomia ponderal index infant anthropometry <p>Objectives. To determine if, and to what extent maternal adipokines and glucose metabolism are associated with infant anthropometry at birth for obese and overweight pregnant mothers.</p><p>Design. Prospective cohort study</p><p>Subjects. Fifty-two healthy, non-smoking, overweight and obese pregnant women (pregravid BMI = 25) between 18 and 40 years old were recruited from the greater Cincinnati metropolitan area.</p><p>Methods. Pregravid body mass index (BMI= kg/m2) was derived from self-reported anthropometric data. A fasting venous blood sample was collected at 26 weeks gestation to assess maternal adipokines and glucose metabolism. HOMA-IR was calculated from fasting glucose and insulin values. Infant anthropometry was self-reported by the mother following delivery. Fetal overgrowth was defined three ways; as macrosomia for infants = 4000 grams at birth; as large-for-gestational-age (LGA) for birthweight =90th percentile for gestational age, and as ponderal index =90th percentile for weight-to-length ratio.</p><p>Results. Infant ponderal index was positively correlated with maternal insulin concentration (r=+0.324, P<0.05) and HOMA-IR (r=+0.292, P<0.05). Maternal insulin explained 16% of the variance in ponderal index (R2 = .16, F = 7.32, P < 0.01). </p><p>Conclusion. Obese pregnant women have a metabolic profile similar to women diagnosed with gestational diabetes mellitus, and experience insulin resistance, inflammation, and the subsequent effects on fetal growth. Insulin resistance remains the most significant predictor of fetal overgrowth in this population. In this study, the maternal adipokines leptin, adiponectin, IL-6 and TNF-a were not associated with infant anthropometry at birth.</p> 2011-08-04 English text University of Cincinnati / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=ucin1307125407 http://rave.ohiolink.edu/etdc/view?acc_num=ucin1307125407 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws. |
| collection |
NDLTD |
| language |
English |
| sources |
NDLTD |
| topic |
Nutrition pregnancy insulin resistance adipokines macrosomia ponderal index infant anthropometry |
| spellingShingle |
Nutrition pregnancy insulin resistance adipokines macrosomia ponderal index infant anthropometry Gardner, Alison Association of Maternal Adipokines with Infant Anthropometry in Obese, Pregnant Women |
| author |
Gardner, Alison |
| author_facet |
Gardner, Alison |
| author_sort |
Gardner, Alison |
| title |
Association of Maternal Adipokines with Infant Anthropometry in Obese, Pregnant Women |
| title_short |
Association of Maternal Adipokines with Infant Anthropometry in Obese, Pregnant Women |
| title_full |
Association of Maternal Adipokines with Infant Anthropometry in Obese, Pregnant Women |
| title_fullStr |
Association of Maternal Adipokines with Infant Anthropometry in Obese, Pregnant Women |
| title_full_unstemmed |
Association of Maternal Adipokines with Infant Anthropometry in Obese, Pregnant Women |
| title_sort |
association of maternal adipokines with infant anthropometry in obese, pregnant women |
| publisher |
University of Cincinnati / OhioLINK |
| publishDate |
2011 |
| url |
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1307125407 |
| work_keys_str_mv |
AT gardneralison associationofmaternaladipokineswithinfantanthropometryinobesepregnantwomen |
| _version_ |
1719433386991288320 |