The Effects of Fish Oil (EPA+DHA) on Chronic Ventilator Patients in a Long Term Acute Care Setting: A Randomized Control Trial

The Effects of Fish Oil (EPA+DHA) on Chronic Ventilator Patients in a Long Term Acute Care Setting: A Randomized Control Trial

Bibliographic Details
Main Author: Harvey, Jessica C.
Language:English
Published: University of Cincinnati / OhioLINK 2011
Subjects:
Nutrition
Omega-3 fatty acids
EPA
DHA
mechanical ventilation
LTACH
inflammation
Online Access:http://rave.ohiolink.edu/etdc/view?acc_num=ucin1307125476
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spelling ndltd-OhioLink-oai-etd.ohiolink.edu-ucin13071254762021-08-03T06:14:49Z The Effects of Fish Oil (EPA+DHA) on Chronic Ventilator Patients in a Long Term Acute Care Setting: A Randomized Control Trial Harvey, Jessica C. Nutrition Omega-3 fatty acids EPA DHA mechanical ventilation LTACH inflammation Purpose: The aim of this study was to determine whether patients in a long term acute care setting who received an enteral supplement containing EPA+DHA, would have a shorter weaning time from the ventilator, a decrease in length of hospital stay, decreased inflammatory markers, and number of infections from baseline to post-treatment compared to patients who received a placebo of normal saline solution.Methods: Nine participants who required mechanical ventilation and enteral nutrition support in a long term acute care hospital were randomized to either receive the treatment fish oil (n=5) or the placebo saline solution (n=4). Participants in the treatment group were given 8g fish oil per day through the enteral feeding tube for 14 days. Subjects randomized to the control group received a blinded saline solution for 14 days. All enteral supplement formulations were createdby a certified pharmacist.Results: There were no significant differences between the treatment and control groups in regards to time to weaning, percent of days on the ventilator, or length of hospital stay. Inflammatory markers did not significantly decrease in either group from baseline to posttreatment. There was a trend towards a lower rate of infection in the treatment group compared to the control group, however these results were not significant.Conclusion: The results of this randomized double blind clinical trial suggest that adding fish oil(EPA/DHA) to enteral formulas does not result in reduced weaning time for patients on a ventilator, decreased length of hospital stay, or markers of inflammation. Additional researchneeds to be conducted with a larger group of participants to determine whether a high dose of EPA +DHA from fish oil can decrease inflammation in this specific population. 2011-08-04 English text University of Cincinnati / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=ucin1307125476 http://rave.ohiolink.edu/etdc/view?acc_num=ucin1307125476 unrestricted This thesis or dissertation is protected by copyright: some rights reserved. It is licensed for use under a Creative Commons license. Specific terms and permissions are available from this document's record in the OhioLINK ETD Center.
collection NDLTD
language English
sources NDLTD
topic Nutrition
Omega-3 fatty acids
EPA
DHA
mechanical ventilation
LTACH
inflammation
spellingShingle Nutrition
Omega-3 fatty acids
EPA
DHA
mechanical ventilation
LTACH
inflammation
Harvey, Jessica C.
The Effects of Fish Oil (EPA+DHA) on Chronic Ventilator Patients in a Long Term Acute Care Setting: A Randomized Control Trial
author Harvey, Jessica C.
author_facet Harvey, Jessica C.
author_sort Harvey, Jessica C.
title The Effects of Fish Oil (EPA+DHA) on Chronic Ventilator Patients in a Long Term Acute Care Setting: A Randomized Control Trial
title_short The Effects of Fish Oil (EPA+DHA) on Chronic Ventilator Patients in a Long Term Acute Care Setting: A Randomized Control Trial
title_full The Effects of Fish Oil (EPA+DHA) on Chronic Ventilator Patients in a Long Term Acute Care Setting: A Randomized Control Trial
title_fullStr The Effects of Fish Oil (EPA+DHA) on Chronic Ventilator Patients in a Long Term Acute Care Setting: A Randomized Control Trial
title_full_unstemmed The Effects of Fish Oil (EPA+DHA) on Chronic Ventilator Patients in a Long Term Acute Care Setting: A Randomized Control Trial
title_sort effects of fish oil (epa+dha) on chronic ventilator patients in a long term acute care setting: a randomized control trial
publisher University of Cincinnati / OhioLINK
publishDate 2011
url http://rave.ohiolink.edu/etdc/view?acc_num=ucin1307125476
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AT harveyjessicac effectsoffishoilepadhaonchronicventilatorpatientsinalongtermacutecaresettingarandomizedcontroltrial
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