Hormone Phenotypes and the Timing of Pubertal Milestones in a Longitudinal Cohort of Girls

Hormone Phenotypes and the Timing of Pubertal Milestones in a Longitudinal Cohort of Girls

Bibliographic Details
Main Author: Fassler, Cecily
Language:English
Published: University of Cincinnati / OhioLINK 2019
Subjects:
Epidemiology
menarche
puberty
hormones
phenotype
cluster
Online Access:http://rave.ohiolink.edu/etdc/view?acc_num=ucin1554212951371174
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spelling ndltd-OhioLink-oai-etd.ohiolink.edu-ucin15542129513711742021-08-03T07:09:47Z Hormone Phenotypes and the Timing of Pubertal Milestones in a Longitudinal Cohort of Girls Fassler, Cecily Epidemiology menarche puberty hormones phenotype cluster Objectives. The primary objective of this research project was to use longitudinal cohort data and quantitative research methods to identify sex hormone phenotypes around the time of thelarche. A second objective of the research was to determine if the ages of pubertal milestones (thelarche, pubarche, and menarche) are associated with a hormone phenotype. Identifying these phenotypes will aid in understanding the biological mechanisms underlying differences in age at pubertal development. Methods. We measured four sex hormones, DHEA-S, estrone, estradiol, and testosterone, at five time periods relative to onset of thelarche (time=-18,-12,-6, 0,+6) in 269 girls from the greater Cincinnati area. Principal components analysis was performed to select a subset of relevant hormone variables. Cluster Analysis was then applied to identify phenotypes of girls based on the hormone variables. Differences in demographic, anthropometric measurements and age at pubertal maturation events between the phenotypes were tested with the Kruskal-Wallis statistic and Chi-Square tests. Cox proportional hazard survival models were used to determine if different phenotypes were associated with ages of thelarche, pubarche, and menarche while controlling or race, caregiver education, mother’s age of menarche and body mass just prior to the age of the maturation event.Results. Principal component analysis yielded three components accounting for 74% of the shared variability among our initial phenotypic variables. Cluster analysis then identified four distinct hormone phenotypes. Phenotype 1 (n=42) was defined as girls with high DHEA, and high testosterone and estrone; Phenotype 2 (n=37) was girls with very high estradiol, and high testosterone and estrone; Phenotype 3 (n=74) was girls who had lower hormone values for all hormones except DHEAS; and Phenotype 4 (n=96) was defined by girls with very low hormones. Survival analysis showed different risks of earlier ages of thelarche, pubarche, and menarche between the phenotypes. Conclusions. Principal component and cluster analysis identified four meaningful and distinct hormone profile phenotypes among young girls indicating the heterogeneity of hormone profiles around pubertal timing. Furthermore, survival analysis confirmed the heterogeneity of the phenotypes and established the temporal stability of the phenotypes by confirming differentiation of risk for ages of thelarche, pubarche and menarche between the phenotypes. These analyses help us understand the rich interplay of hormones during pubertal maturation, but also give us insight in to the developmental onset of hormone related adult diseases. 2019-06-07 English text University of Cincinnati / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=ucin1554212951371174 http://rave.ohiolink.edu/etdc/view?acc_num=ucin1554212951371174 unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws.
collection NDLTD
language English
sources NDLTD
topic Epidemiology
menarche
puberty
hormones
phenotype
cluster
spellingShingle Epidemiology
menarche
puberty
hormones
phenotype
cluster
Fassler, Cecily
Hormone Phenotypes and the Timing of Pubertal Milestones in a Longitudinal Cohort of Girls
author Fassler, Cecily
author_facet Fassler, Cecily
author_sort Fassler, Cecily
title Hormone Phenotypes and the Timing of Pubertal Milestones in a Longitudinal Cohort of Girls
title_short Hormone Phenotypes and the Timing of Pubertal Milestones in a Longitudinal Cohort of Girls
title_full Hormone Phenotypes and the Timing of Pubertal Milestones in a Longitudinal Cohort of Girls
title_fullStr Hormone Phenotypes and the Timing of Pubertal Milestones in a Longitudinal Cohort of Girls
title_full_unstemmed Hormone Phenotypes and the Timing of Pubertal Milestones in a Longitudinal Cohort of Girls
title_sort hormone phenotypes and the timing of pubertal milestones in a longitudinal cohort of girls
publisher University of Cincinnati / OhioLINK
publishDate 2019
url http://rave.ohiolink.edu/etdc/view?acc_num=ucin1554212951371174
work_keys_str_mv AT fasslercecily hormonephenotypesandthetimingofpubertalmilestonesinalongitudinalcohortofgirls
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