Effects of Voluntary Physical Rehabilitation on Neurogenesis In SVZ And Functional Recovery After Ischemic Stroke

Effects of Voluntary Physical Rehabilitation on Neurogenesis In SVZ And Functional Recovery After Ischemic Stroke

Bibliographic Details
Main Author: Balakrishnan, Anuranjani
Language:English
Published: Wright State University / OhioLINK 2018
Subjects:
Neurosciences
Immunology
Neurobiology
Rehabilitation
Physiology
neurogenesis
doublecortin
rehabilitation
ischemic stroke
ipsilateral recovery
contralateral recovery
Montoya Staircase
Online Access:http://rave.ohiolink.edu/etdc/view?acc_num=wright1537186443944433
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spelling ndltd-OhioLink-oai-etd.ohiolink.edu-wright15371864439444332021-08-03T07:08:29Z Effects of Voluntary Physical Rehabilitation on Neurogenesis In SVZ And Functional Recovery After Ischemic Stroke Balakrishnan, Anuranjani Neurosciences Immunology Neurobiology Rehabilitation Physiology neurogenesis doublecortin rehabilitation ischemic stroke ipsilateral recovery contralateral recovery Montoya Staircase Stroke is the leading cause of long-term disability and 87% of all strokes are due to ischemic strokes. In this current study, we examined whether voluntary physical rehabilitation can influence neurogenesis (measured by Doublecortin) in the subventricular zone and show improved motor functional recovery in 10-12 month female rats after ischemia. We saw a significant increase in the neurogenesis (measured by doublecortin) of all three regions (anterior, middle and posterior) of SVZ in the rehab animals compared to control group when using a two-way variance ANOVA test, although we were unable to see significant differences in paired t-tests of similar regions for control and rehab animals. The control animals showed a significant increase in contralateral functional recovery of 56% with rehab animals displaying a recovery of 23%. These findings suggest that the physical rehabilitation showed increased neurogenesis in the SVZ but did not translate to greater contralateral functional recovery. 2018-12-17 English text Wright State University / OhioLINK http://rave.ohiolink.edu/etdc/view?acc_num=wright1537186443944433 http://rave.ohiolink.edu/etdc/view?acc_num=wright1537186443944433 unrestricted This thesis or dissertation is protected by copyright: some rights reserved. It is licensed for use under a Creative Commons license. Specific terms and permissions are available from this document's record in the OhioLINK ETD Center.
collection NDLTD
language English
sources NDLTD
topic Neurosciences
Immunology
Neurobiology
Rehabilitation
Physiology
neurogenesis
doublecortin
rehabilitation
ischemic stroke
ipsilateral recovery
contralateral recovery
Montoya Staircase
spellingShingle Neurosciences
Immunology
Neurobiology
Rehabilitation
Physiology
neurogenesis
doublecortin
rehabilitation
ischemic stroke
ipsilateral recovery
contralateral recovery
Montoya Staircase
Balakrishnan, Anuranjani
Effects of Voluntary Physical Rehabilitation on Neurogenesis In SVZ And Functional Recovery After Ischemic Stroke
author Balakrishnan, Anuranjani
author_facet Balakrishnan, Anuranjani
author_sort Balakrishnan, Anuranjani
title Effects of Voluntary Physical Rehabilitation on Neurogenesis In SVZ And Functional Recovery After Ischemic Stroke
title_short Effects of Voluntary Physical Rehabilitation on Neurogenesis In SVZ And Functional Recovery After Ischemic Stroke
title_full Effects of Voluntary Physical Rehabilitation on Neurogenesis In SVZ And Functional Recovery After Ischemic Stroke
title_fullStr Effects of Voluntary Physical Rehabilitation on Neurogenesis In SVZ And Functional Recovery After Ischemic Stroke
title_full_unstemmed Effects of Voluntary Physical Rehabilitation on Neurogenesis In SVZ And Functional Recovery After Ischemic Stroke
title_sort effects of voluntary physical rehabilitation on neurogenesis in svz and functional recovery after ischemic stroke
publisher Wright State University / OhioLINK
publishDate 2018
url http://rave.ohiolink.edu/etdc/view?acc_num=wright1537186443944433
work_keys_str_mv AT balakrishnananuranjani effectsofvoluntaryphysicalrehabilitationonneurogenesisinsvzandfunctionalrecoveryafterischemicstroke
_version_ 1719454659576332288

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