Molecular Evolution of Pregnancy
<p> Unraveling the molecular etiology of a novel phenotype is still a major challenge. Mammalian pregnancy, a novel phenotype, preserves its stepwise evolution in extant species, which gives us additional tools to use to begin to unravel its evolution. Within this thesis, the evolution of thre...
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The University of Chicago
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ndltd-PROQUEST-oai-pqdtoai.proquest.com-108171982018-07-09T18:51:57Z Molecular Evolution of Pregnancy Mika, Katelyn Marie Molecular biology|Genetics|Evolution & development <p> Unraveling the molecular etiology of a novel phenotype is still a major challenge. Mammalian pregnancy, a novel phenotype, preserves its stepwise evolution in extant species, which gives us additional tools to use to begin to unravel its evolution. Within this thesis, the evolution of three components of pregnancy are explored- the regulation of <i>TAP2</i> expression, the regulation of HLA-F expression, and the possible role of transposable elements in rewiring the regulatory networks underlying major gene expression shifts at the maternal-fetal interface.</p><p> The University of Chicago 2018-07-04 00:00:00.0 thesis http://pqdtopen.proquest.com/#viewpdf?dispub=10817198 EN |
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NDLTD |
language |
EN |
sources |
NDLTD |
topic |
Molecular biology|Genetics|Evolution & development |
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Molecular biology|Genetics|Evolution & development Mika, Katelyn Marie Molecular Evolution of Pregnancy |
description |
<p> Unraveling the molecular etiology of a novel phenotype is still a major challenge. Mammalian pregnancy, a novel phenotype, preserves its stepwise evolution in extant species, which gives us additional tools to use to begin to unravel its evolution. Within this thesis, the evolution of three components of pregnancy are explored- the regulation of <i>TAP2</i> expression, the regulation of HLA-F expression, and the possible role of transposable elements in rewiring the regulatory networks underlying major gene expression shifts at the maternal-fetal interface.</p><p> |
author |
Mika, Katelyn Marie |
author_facet |
Mika, Katelyn Marie |
author_sort |
Mika, Katelyn Marie |
title |
Molecular Evolution of Pregnancy |
title_short |
Molecular Evolution of Pregnancy |
title_full |
Molecular Evolution of Pregnancy |
title_fullStr |
Molecular Evolution of Pregnancy |
title_full_unstemmed |
Molecular Evolution of Pregnancy |
title_sort |
molecular evolution of pregnancy |
publisher |
The University of Chicago |
publishDate |
2018 |
url |
http://pqdtopen.proquest.com/#viewpdf?dispub=10817198 |
work_keys_str_mv |
AT mikakatelynmarie molecularevolutionofpregnancy |
_version_ |
1718709837576011776 |