Molecular Evolution of Pregnancy

Molecular Evolution of Pregnancy

<p> Unraveling the molecular etiology of a novel phenotype is still a major challenge. Mammalian pregnancy, a novel phenotype, preserves its stepwise evolution in extant species, which gives us additional tools to use to begin to unravel its evolution. Within this thesis, the evolution of thre...

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Main Author: Mika, Katelyn Marie
Language:EN
Published: The University of Chicago 2018
Subjects:
Molecular biology|Genetics|Evolution & development
Online Access:http://pqdtopen.proquest.com/#viewpdf?dispub=10817198
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spelling ndltd-PROQUEST-oai-pqdtoai.proquest.com-108171982018-07-09T18:51:57Z Molecular Evolution of Pregnancy Mika, Katelyn Marie Molecular biology|Genetics|Evolution & development <p> Unraveling the molecular etiology of a novel phenotype is still a major challenge. Mammalian pregnancy, a novel phenotype, preserves its stepwise evolution in extant species, which gives us additional tools to use to begin to unravel its evolution. Within this thesis, the evolution of three components of pregnancy are explored- the regulation of <i>TAP2</i> expression, the regulation of HLA-F expression, and the possible role of transposable elements in rewiring the regulatory networks underlying major gene expression shifts at the maternal-fetal interface.</p><p> The University of Chicago 2018-07-04 00:00:00.0 thesis http://pqdtopen.proquest.com/#viewpdf?dispub=10817198 EN
collection NDLTD
language EN
sources NDLTD
topic Molecular biology|Genetics|Evolution & development
spellingShingle Molecular biology|Genetics|Evolution & development
Mika, Katelyn Marie
Molecular Evolution of Pregnancy
description <p> Unraveling the molecular etiology of a novel phenotype is still a major challenge. Mammalian pregnancy, a novel phenotype, preserves its stepwise evolution in extant species, which gives us additional tools to use to begin to unravel its evolution. Within this thesis, the evolution of three components of pregnancy are explored- the regulation of <i>TAP2</i> expression, the regulation of HLA-F expression, and the possible role of transposable elements in rewiring the regulatory networks underlying major gene expression shifts at the maternal-fetal interface.</p><p>
author Mika, Katelyn Marie
author_facet Mika, Katelyn Marie
author_sort Mika, Katelyn Marie
title Molecular Evolution of Pregnancy
title_short Molecular Evolution of Pregnancy
title_full Molecular Evolution of Pregnancy
title_fullStr Molecular Evolution of Pregnancy
title_full_unstemmed Molecular Evolution of Pregnancy
title_sort molecular evolution of pregnancy
publisher The University of Chicago
publishDate 2018
url http://pqdtopen.proquest.com/#viewpdf?dispub=10817198
work_keys_str_mv AT mikakatelynmarie molecularevolutionofpregnancy
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