The capillary-centric model of cardiac coupling-as-thermodynamics
<p> Models of ventricular-arterial coupling (VAC) have historically described the heart as a function of its energetic interaction with the arterial system. However, these models either represent the dynamic, adaptive cardiovascular system (CVS) in isolation or sacrifice cardiac mechanics to u...
Main Author: | |
---|---|
Language: | EN |
Published: |
North Dakota State University
2015
|
Subjects: | |
Online Access: | http://pqdtopen.proquest.com/#viewpdf?dispub=1606114 |
id |
ndltd-PROQUEST-oai-pqdtoai.proquest.com-1606114 |
---|---|
record_format |
oai_dc |
spelling |
ndltd-PROQUEST-oai-pqdtoai.proquest.com-16061142016-01-01T04:00:36Z The capillary-centric model of cardiac coupling-as-thermodynamics Taylor, Andrew James David Biomedical engineering|Medicine|Physiology <p> Models of ventricular-arterial coupling (VAC) have historically described the heart as a function of its energetic interaction with the arterial system. However, these models either represent the dynamic, adaptive cardiovascular system (CVS) in isolation or sacrifice cardiac mechanics to use simplified, time-averaged values across the cardiac cycle. In this thesis a facsimile CVS is constructed that characterizes ventricular-arterial interactions with intact cardiac mechanics as a function of whole-body thermo-fluid homeostatic regulation. Simulation results indicate proportional-integral (PI) control of heart rate and arterial resistance is conditionally sufficient to maintain body temperature during square-wave exercise, but further elements may be required to mimic genuine physiological responses. These simulations of the primitive model lay the framework of capillary-centric VAC through the perspective of coupling-as-thermodynamics.</p> North Dakota State University 2015-12-31 00:00:00.0 thesis http://pqdtopen.proquest.com/#viewpdf?dispub=1606114 EN |
collection |
NDLTD |
language |
EN |
sources |
NDLTD |
topic |
Biomedical engineering|Medicine|Physiology |
spellingShingle |
Biomedical engineering|Medicine|Physiology Taylor, Andrew James David The capillary-centric model of cardiac coupling-as-thermodynamics |
description |
<p> Models of ventricular-arterial coupling (VAC) have historically described the heart as a function of its energetic interaction with the arterial system. However, these models either represent the dynamic, adaptive cardiovascular system (CVS) in isolation or sacrifice cardiac mechanics to use simplified, time-averaged values across the cardiac cycle. In this thesis a facsimile CVS is constructed that characterizes ventricular-arterial interactions with intact cardiac mechanics as a function of whole-body thermo-fluid homeostatic regulation. Simulation results indicate proportional-integral (PI) control of heart rate and arterial resistance is conditionally sufficient to maintain body temperature during square-wave exercise, but further elements may be required to mimic genuine physiological responses. These simulations of the primitive model lay the framework of capillary-centric VAC through the perspective of coupling-as-thermodynamics.</p> |
author |
Taylor, Andrew James David |
author_facet |
Taylor, Andrew James David |
author_sort |
Taylor, Andrew James David |
title |
The capillary-centric model of cardiac coupling-as-thermodynamics |
title_short |
The capillary-centric model of cardiac coupling-as-thermodynamics |
title_full |
The capillary-centric model of cardiac coupling-as-thermodynamics |
title_fullStr |
The capillary-centric model of cardiac coupling-as-thermodynamics |
title_full_unstemmed |
The capillary-centric model of cardiac coupling-as-thermodynamics |
title_sort |
capillary-centric model of cardiac coupling-as-thermodynamics |
publisher |
North Dakota State University |
publishDate |
2015 |
url |
http://pqdtopen.proquest.com/#viewpdf?dispub=1606114 |
work_keys_str_mv |
AT taylorandrewjamesdavid thecapillarycentricmodelofcardiaccouplingasthermodynamics AT taylorandrewjamesdavid capillarycentricmodelofcardiaccouplingasthermodynamics |
_version_ |
1718158079234670592 |