Molecular Mechanisms of the Cooperation between Rac1/1b GTPases and the Canonical Wnt Signaling Pathway in Colorectal Cancer
Aberrant activation of the canonical Wnt signaling pathway accounts for the vast majority of colorectal cancers. The Rac1 GTPase is overexpressed in colon cancer, and its splice variant, Rac1b, is preferentially expressed in colon tumours. Rac1 and Rac1b have both been previously shown to crosstal...
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| Language: | en_ca |
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2010
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| Online Access: | http://hdl.handle.net/1807/26158 |