Effect of Potassium and Magnesium Doping on Sintering and Properties of Calcium Polyphosphate

Porous constructs of calcium polyphosphate (CPP) are under investigation as a substrate for tissue engineering of cartilage for repair of osteochondral defects. Previous studies have shown that CPP has the required features to satisfy these requirements. However, its degradation rate is lower than d...

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Bibliographic Details
Main Author: Abbarin, Nastaran
Other Authors: Grynpas, Marc D.
Language:en_ca
Published: 2011
Subjects:
CPP
Online Access:http://hdl.handle.net/1807/29460
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spelling ndltd-TORONTO-oai-tspace.library.utoronto.ca-1807-294602013-11-01T04:11:38ZEffect of Potassium and Magnesium Doping on Sintering and Properties of Calcium PolyphosphateAbbarin, Nastarancalcium polyphosphateCPPdopingmagnesiumpotassiumdegradation07940541Porous constructs of calcium polyphosphate (CPP) are under investigation as a substrate for tissue engineering of cartilage for repair of osteochondral defects. Previous studies have shown that CPP has the required features to satisfy these requirements. However, its degradation rate is lower than desired. This study investigated the effect of doping with MgCO3, MgCl2, K2CO3 or KCl at a molar ratio of M/Ca = 0.02 on sintering and in vitro degradation behavior of CPP. Doping with magnesium or potassium improved the tensile and compressive strengths of CPP at similar porosities. After 15 days of aging in phosphate buffer saline, the rate of tensile strength loss was faster for the doped CPP groups than undoped CPP. The chemical degradation rate of Mg-doped CPP groups was the fastest among CPP groups. The chemical degradation rate of K-doped CPP groups was slower than undoped CPP.Grynpas, Marc D.Coyle, Thomas W.2011-062011-08-10T20:24:47ZNO_RESTRICTION2011-08-10T20:24:47Z2011-08-10Thesishttp://hdl.handle.net/1807/29460en_ca
collection NDLTD
language en_ca
sources NDLTD
topic calcium polyphosphate
CPP
doping
magnesium
potassium
degradation
0794
0541
spellingShingle calcium polyphosphate
CPP
doping
magnesium
potassium
degradation
0794
0541
Abbarin, Nastaran
Effect of Potassium and Magnesium Doping on Sintering and Properties of Calcium Polyphosphate
description Porous constructs of calcium polyphosphate (CPP) are under investigation as a substrate for tissue engineering of cartilage for repair of osteochondral defects. Previous studies have shown that CPP has the required features to satisfy these requirements. However, its degradation rate is lower than desired. This study investigated the effect of doping with MgCO3, MgCl2, K2CO3 or KCl at a molar ratio of M/Ca = 0.02 on sintering and in vitro degradation behavior of CPP. Doping with magnesium or potassium improved the tensile and compressive strengths of CPP at similar porosities. After 15 days of aging in phosphate buffer saline, the rate of tensile strength loss was faster for the doped CPP groups than undoped CPP. The chemical degradation rate of Mg-doped CPP groups was the fastest among CPP groups. The chemical degradation rate of K-doped CPP groups was slower than undoped CPP.
author2 Grynpas, Marc D.
author_facet Grynpas, Marc D.
Abbarin, Nastaran
author Abbarin, Nastaran
author_sort Abbarin, Nastaran
title Effect of Potassium and Magnesium Doping on Sintering and Properties of Calcium Polyphosphate
title_short Effect of Potassium and Magnesium Doping on Sintering and Properties of Calcium Polyphosphate
title_full Effect of Potassium and Magnesium Doping on Sintering and Properties of Calcium Polyphosphate
title_fullStr Effect of Potassium and Magnesium Doping on Sintering and Properties of Calcium Polyphosphate
title_full_unstemmed Effect of Potassium and Magnesium Doping on Sintering and Properties of Calcium Polyphosphate
title_sort effect of potassium and magnesium doping on sintering and properties of calcium polyphosphate
publishDate 2011
url http://hdl.handle.net/1807/29460
work_keys_str_mv AT abbarinnastaran effectofpotassiumandmagnesiumdopingonsinteringandpropertiesofcalciumpolyphosphate
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