Effects of Proteasome Inhibition on Tau Protein
The ubiquitin-proteasome system is an important proteolytic pathway implicated in the formation of neurofibrillary tangles from hyperphosphorylated tau, a pathological hallmark of tauopathies such as Alzheimer’s disease. We hypothesize that proteasome inhibition will result in tau accumulation, lead...
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| Language: | en_ca |
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2011
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| Online Access: | http://hdl.handle.net/1807/30547 |
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