Predicting the Risk of Traumatic Lumbar Punctures in Children with Acute Lymphoblastic Leukemia: a Retrospective Cohort Study using Repeated-measures Analyses
Traumatic lumbar punctures (TLPs) in children with acute lymphoblastic leukemia are associated with a poorer prognosis. The objective of this study was to determine risk factors for TLPs using a retrospective cohort. We compared and contrasted three different regression methods for the analysis of r...
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ndltd-TORONTO-oai-tspace.library.utoronto.ca-1807-335242013-04-19T20:03:33ZPredicting the Risk of Traumatic Lumbar Punctures in Children with Acute Lymphoblastic Leukemia: a Retrospective Cohort Study using Repeated-measures AnalysesShaikh, Furqanleukemialumbar punctures0564Traumatic lumbar punctures (TLPs) in children with acute lymphoblastic leukemia are associated with a poorer prognosis. The objective of this study was to determine risk factors for TLPs using a retrospective cohort. We compared and contrasted three different regression methods for the analysis of repeated-measures data. In the multivariable model using generalized estimating equations, variables significantly associated with TLPs were age < l year or ≥ 10 years; body mass index percentile ≥ 95; platelet counts < 100 x 103/µL; fewer days since previous LP, and a preceding TLP. The same variables, with similar estimates and confidence-intervals, were identified by the random-effects model. In a fixed-effects model where each patient was used as their own control, days since prior LP and the effect of using image-guidance were significant. Random-effects and GEE lead to similar conclusions, whereas fixed-effects discards between-subject comparisons and leads to different estimates and interpretation of results.Sung, Lillian2012-112012-11-26T20:42:19ZNO_RESTRICTION2012-11-26T20:42:19Z2012-11-26Thesishttp://hdl.handle.net/1807/33524en_ca |
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leukemia lumbar punctures 0564 |
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leukemia lumbar punctures 0564 Shaikh, Furqan Predicting the Risk of Traumatic Lumbar Punctures in Children with Acute Lymphoblastic Leukemia: a Retrospective Cohort Study using Repeated-measures Analyses |
description |
Traumatic lumbar punctures (TLPs) in children with acute lymphoblastic leukemia are associated with a poorer prognosis. The objective of this study was to determine risk factors for TLPs using a retrospective cohort. We compared and contrasted three different regression methods for the analysis of repeated-measures data. In the multivariable model using generalized estimating equations, variables significantly associated with TLPs were age < l year or ≥ 10 years; body mass index percentile ≥ 95; platelet counts < 100 x 103/µL; fewer days since previous LP, and a preceding TLP. The same variables, with similar estimates and confidence-intervals, were identified by the random-effects model. In a fixed-effects model where each patient was used as their own control, days since prior LP and the effect of using image-guidance were significant. Random-effects and GEE lead to similar conclusions, whereas fixed-effects discards between-subject comparisons and leads to different estimates and interpretation of results. |
author2 |
Sung, Lillian |
author_facet |
Sung, Lillian Shaikh, Furqan |
author |
Shaikh, Furqan |
author_sort |
Shaikh, Furqan |
title |
Predicting the Risk of Traumatic Lumbar Punctures in Children with Acute Lymphoblastic Leukemia: a Retrospective Cohort Study using Repeated-measures Analyses |
title_short |
Predicting the Risk of Traumatic Lumbar Punctures in Children with Acute Lymphoblastic Leukemia: a Retrospective Cohort Study using Repeated-measures Analyses |
title_full |
Predicting the Risk of Traumatic Lumbar Punctures in Children with Acute Lymphoblastic Leukemia: a Retrospective Cohort Study using Repeated-measures Analyses |
title_fullStr |
Predicting the Risk of Traumatic Lumbar Punctures in Children with Acute Lymphoblastic Leukemia: a Retrospective Cohort Study using Repeated-measures Analyses |
title_full_unstemmed |
Predicting the Risk of Traumatic Lumbar Punctures in Children with Acute Lymphoblastic Leukemia: a Retrospective Cohort Study using Repeated-measures Analyses |
title_sort |
predicting the risk of traumatic lumbar punctures in children with acute lymphoblastic leukemia: a retrospective cohort study using repeated-measures analyses |
publishDate |
2012 |
url |
http://hdl.handle.net/1807/33524 |
work_keys_str_mv |
AT shaikhfurqan predictingtheriskoftraumaticlumbarpuncturesinchildrenwithacutelymphoblasticleukemiaaretrospectivecohortstudyusingrepeatedmeasuresanalyses |
_version_ |
1716582652184625152 |