| Summary: | 碩士 === 中國醫藥學院 === 藥物化學研究所 === 81 === A series of 1-substituted 5-methyl-3-phenylfuro[3,2-c]
pyrazoles(III1-11) and its intermediates (II1-13) have been
synthesized,and evaluated for antipletelet activities.Most of
them showed significant effect on the inhibition of platelet
aggregation that induced by collagen and arachidonic acid.
Among them 5-methyl-2-furyl phenyl ketone 3',4'-dichlorophenyl
hydrazone (II6) was the most promising and therefore the action
mechanism of this compound was further studied.When 5-methyl-2
-furyl phenyl ketone 4-chlorophenylhydrazone treat with lead
tetraacetate,boron trifluoride etherate to carry out oxidative
cyclization,side product p-chlorobiphenyl also obtained.
Therefore we react substituted pphenylhydrazine with benzene
or toluene in the present of lead tetraacetate,we can obtain
high yield of biphenyl deratives.The application and the
really mechanism were worthy of further studied.
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