| Summary: | 碩士 === 中原大學 === 醫學工程學系 === 82 === Since hemodialysis has applied to chronic renal failure
patients,it is still a goal to assess the completeness and
adequacy of hemodialysis.This paper is to develop software
program to evaluate urea kinetics for quantifying hemodialysis
therapy. In the software program system, one-pool model and
two- pool model are used for analysis of urea kinetics. Both
constant and variable volumes dialysis are also considered;
model para- meters can be determined with a two BUN or a three
BUN methods; during dialysis, the operation mode can follow a
conventional or a optimal schemes; the dialysis frequency of
the patient can be taken with a two times or a three times per
week. The optimal dialysis is the main feature of the program
system. The time-average blood urea nitrogen (TAC) and the
protein catabolic rate (PCR) are selected as the measures of
prescription effectiveness. The TAC was suggested by the
National Cooperative Dialysis Study (NCDS,USA) as the major
outcome parameter.The pro- gram estabilished in the paper can
provide the clinicians pre- scribing dialysis to achieve ideal
TAC and ideal PCR for improve- ment of patient care. The
results of theoretical calculation and clinical data
applications depict that the system developed in this paper is
available clinically. Besides talking above,we can find the
correlation coefficients are very high for useing one- pool
model and two-pool model、a two BUN and a three BUN methods to
calculate any one of these parameters, which are production
rate of BUN (G), BUN distribution volume V and TAC by
statistical analysis. It means that these methods are
consistency. In the beta-2-microglobulin(β2-M) simulation, we
can calcul- ate the production rate of β2-M (Gb) by a two BUN
method or a three BUN method. The Gb not only include
production rate of cellular catabolism (Gc), but also include
production rate of immunological response (Gi).
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