Effect of Addition n-Hexadecane on Penicillin Fermentation
碩士 === 國立成功大學 === 化學工程研究所 === 82 === Oxygen supply is usually a limiting step in aerobic bio- reaction system. To overcome this drawback, hydrocarbons are added to a fermentatinon medium to increase the oxygen transfer rate. In this study, the fermentatio...
| Main Authors: | , |
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| Other Authors: | |
| Format: | Others |
| Language: | zh-TW |
| Published: |
1994
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| Online Access: | http://ndltd.ncl.edu.tw/handle/98679779761666854399 |
| Summary: | 碩士 === 國立成功大學 === 化學工程研究所 === 82 === Oxygen supply is usually a limiting step in aerobic bio-
reaction system. To overcome this drawback, hydrocarbons are
added to a fermentatinon medium to increase the oxygen transfer
rate. In this study, the fermentation of Penicillium chysogenum
was employed to investigate the effect of addition of n-hexade-
cane on the mold growth and the production of penicillin.
Experimental results showed that the timing of adding n-
hexadecane to the fermentation medium would effect cell mor-
phology and penicillin productivity. Adding n-hexadecane at
growth phase, the mold would exist as filamentous mycelium (not
pellet) and the penicillin productivity was low. Adding n-
hexadecane at the production phase, the biomass existed as
fluffy loose pellets and high penicillin productivity could be
obtained. We also found that n-hexadecane had a good effect of
anti- foaming. Employing n-hexadecane as the antifoam agent
resulted in higher production rate of penicillin than using
KM-70.
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