| Summary: | 碩士 === 中國醫藥學院 === 中國醫學研究所 === 83 === Endogenous depression is a severe psychotic disorder, including the following symptoms: depressed mood, sleep disturbance, psychomotor and body weight abnormalities, ect. Antidepressants (eg. tricyclic antidepressants) have some effects on depression, but they also have some side effects (eg. drowsiness). In Chinese traditional medicine, Hsiao-Yao-Shan (HYS) had been popularly used to treat "depression" since Ming dynasty. The purpose of this experiment is to evaluate the antidepressant effect of Hsiao-Yao-Shan via the animal model of endogenous depression. According to the animal model of depression proposed by Vogel, neonatal clomipramine (15mg/kg, bid) injection to Sprague-Dawley rats when 8 to 21 day-old for the experimental group, while normal saline (1cc/kg), bid) injection for control group. At the 5 month of age, experimental group was divided randomly into 4 subgroup and with the different treatments: amitriptyline (AMI; 10mg/kg qd), low concentration of HYS (1g/kg), and normal saline (1cc/kg). We check body weight, hormone and behavior change during the treatment course. By using ANOVA to compare the mean values of parameter for five group, and it shows: 1.HYS has significant effect for body weight increment. 2.HYS has the same regulation effect of hormone compared to AMI. 3.HYS increased motor acivity in the open field, while AMI decreased. 4.Both HYS and AMI increased hedonic effect in the sucrose consumption test.
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