| Summary: | 碩士 === 中國醫藥學院 === 中國藥學研究所 === 84 === Wogonin, an active constituent isolated from the root of
Scutellaria baicalensis Georgi (Woogon), a frequently use herb
in China, possesses antiinflammatory, antispasmodic and lipid-
lowering effect. In this study, the pharmacokinetics and
bioavailability of wogonin in rabbits were evaluated.A simple
high-performance liquid chromatographic method was self-
developed for the determination of wogonin in plasma samples.The
pharmacokinetics of wogonin in the rabbits after intravenous
bolus administration of various doses (2,10 or 30 mg/kg) were
well described by a two compartment model. The mean biological
half-lives was about 80 mins. The results also indicated that
the pharmacokinetics of wogonin after I.V. administration are
linear over the 2~30 mg/kg dose range. The bioavailability of
wogonin in rabbits after I.M. administered of 30 mg/kg dose was
50.9%. However, after oral administered 200 mg/kg dose of same
preparation, the bioavailability was only about 1.4%, indicated
that wogonin was pooly absorbed from the GI tract in rabbits.
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