Development of Functional Membrane Containing Thermo-sensitive Poly (N-isopropylacrylamide) Microgel

• Main Authors: Liang, Run-Chu, 梁潤筑
• Other Authors: Chen Ko-Shao, Lin Shan-Yang
• Format: Others
• Language: zh-TW
• Published: 1996
• Online Access: http://ndltd.ncl.edu.tw/handle/76241457804077103194

碩士 === 大同工學院 === 材料工程學系 === 84 === The traditional adhesive bandage covered on the external injuries always hurts the wounded place when we removed the bandage. In order to prevent second injury caused by the traditional adhesive bandage, we try to design a functional membrane with several advantages such as adsorption of the secretion of the injuries, self-adhesion, easy peeling from the wound place and capable of releasing drug to the injuries. This functional membrane was made of acrylic resin, plasticizer and thermo-sensitive poly N-isopropylacrylamide (PNIPAAm) microgels. Sufamethoxazole was used as a model drug. The studies mainly focused on four parts: I. Preparation of the linear thermo-sensitive PNIPAAm and evaluation its phase transition temperature,II. Preparation and characterization of the crosslinking thermo-sensitivePNIPAAm microgels. III. Fabrication of self-adhesion acrylic membranes. IV.Developmemt and evaluation of the functional membrane with thermo-sensitiveand self-adhesion properties. A thermo micro attenuated total reflection/Fourier transform infrared(ATR/FTIR) system with curve-fitting program was used to determine the thermo-dependent behavior of PNIPAAm below and above lower critical solution temperature (LCST). The results indicate that the intermolecular interactions might occurbetween water and polymer when temperature was below LCST. On the other hand,when the temperature was higher than LCST the polymer was coagulated due to the intramolecular interactions between polymers and by hydrophobic effects. There was no significant difference in LCST between crosslinkinged and lineared thermo-sensitive PNIPAAm microgel. When temperature was belowLCST, PNIPAAm microgels were swelling by the hydrophilic effect. Whentemperature was higher than LCST, the microgels were shrinking quickly byhydrophobic effect. The swelling and shrinking behavior was reversible. Theresult suggests that it is capable of adsorbing the secretions from the injuries. Three types of acrylic resins (Eudragit E, Eudragit RL, and Eudragit RS) with four kinds of plasticizers (triacetin, diethyl phthalate (DEP), dibutyl phthalate(DBP), tributyl citrate (TBC)) were used to prepare the self-adhesivemembrane using the solvent evaporation method. The water adsorptionproperties, adhesion strength and membrane stability were examined to screenand evaluate the best formulation. The results indicate that the Eudragit Emembrane with 37 wt% TBC would be the best self- adhesion and stabilityproperties. The PNIPAAm microgel with or without drug previously included in the Eudragit E membrane still represented the thermo-responsive property. The LCST of the PNIPAAm microgels in pseudo-extracellular fluid (PECF) wasabout 30℃. The drug might release completely from the functional membrane after 12 hours in vitro. It concludes that the newly-developed functional membrane not only exhibits the self-adhensive and thermo-responsive absorption properties, butalso is capable of drug release.