| Summary: | 碩士 === 長庚醫學暨工程學院 === 基礎醫學研究所 === 85 === Colorectal cancer is one of the common cancers in Taiwan.
According to health and vital statistics by Department of
Health, Executive Yuan, the death rate of colorectal cancer was
11.62 per 100,000 population in 1995. In fact, the death rate of
this cancer is gradually increasing year after year. Now,
colorectal cancer is the third and highest cause of cancer death
for man and woman, respectively. Epidemiological studies have
indicated that dietary factors as well as genetic factors play
some important role in the development of this cancer.In human
colorectal tumors, specific structural alterations in a number
of genes, including apc, mcc, p53, dcc, L-myc, k-ras and most
recently hMSH2 and hMLH1, have been identified that are
associated with the initiation and progression of this tumor.
The current study included 183 colorectal cancer patients from
Chang Gung Memorial Hospital to examine the alteration of p53,
apc, mcc and L-myc gene in their tumor tissues, and to
investigate the relationship to these alterations and specific
clinico-pathological variables, such as tumor staging,
histology, grading , survival, etc.The results obtained are as
follows: (The frequency of p53 gene alterations was higher in
rectum than in colon. (Loss of heterozygosity of mcc gene was
significantly more common in male patients than female patients.
(The patients with well-differentiated tumors had higher
percentage of SS genotype of L-myc gene than patients with
moderate and poorly differentiated tumor. (Among p53, apc, mcc
and L-myc these four genes examined, male patients appeared to
have more gene alterations than female patients in terms of
total number of alterations. Rectum tumors had higher
alterations than colon tumors. (For TNM stage III colorectal
cancer patients, the patients with abnormal p53 gene who had
received the chemotherapy or radiotherapy showed better survival
than those who had not received the chemotherapy or
radiotherapy. For those have not received the chemotherapy or
radiotherapy TNM stage III patients, an association between p53
alteration and poor survival was also observed.
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