| Summary: | 碩士 === 中國醫藥學院 === 中國藥學研究所 === 85 === Baicalein, an active constituent isolated from the root of
Scutellarir baicalensis GEORGI, a frequently use herb in China,
possesses antioxidationantitumor, anti-inflammatory and lipid-
lowering effect. In this study, thepharmacokinetics and
bioavailability of Baicalein in rabbits were evaluated. A
simple high performance liquid chromatographic method was
developed forthe determination of Baicalein in plasma sample.
The pharmacokinetics of Baicalein in the rabbits after
intravenous bolusadministration of various doses (2,10 and 50
mg/kg) were well described bya two compartment model. The mean
biological half-lives was 71 mins . Theresults also indicated
that the pharmacokinetics of Baicalein after I.V.adminstration
are linear over the 2-50 mg/kg dose range . The
bioavailabilityof Baicalein in rabbits after I.M. administered
of 50 mg/kg dose was 68%.However , after oral administered 250
mg/kg dose of same preparation, thebioavailability was only
about 29%, it indicated that Baicalein was poorlyabsorbed from
the GI tract in rabbits .
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