| Summary: | 碩士 === 中國醫藥學院 === 中國醫學研究所 === 85 === Raynaud's phenomenon (RP) has been reported in 10-44% of the patients with systemic lupus erythematosus (SLE). The pathogenetic mechanism of SLE presenting with RP is compatible with "heat reversal" in Chinese medicine. According to the principle of classic Chinese medicine, heat reversal should be treated with "qing-wen-bai-du-yin(QW)" a Chinese herb prescription.
We proceeded to carry out a double-blind case- controlled study of QW in SLE patients with RP. Ninty-four outpatients with SLE regularly treated with western medicine were selected. Laser Doppler flowmetry (LDF) were performed on them. Among them 25 patients with SLE presenting RP were randomly allocated to two groups. Thirteen patients took QW orally, 12g a day for 8 weeks, and 12 patients were given a placebo. Finger cooling test was applied to induce RP during the examination. Quantitative analysis of the blood perfusion on the volar fingertip of right middle finger was performed before and after treatment.
The results showed that the baseline perfusion of the SLE patients with RP was higher than the SLE patients without RP (p=0.0054). The recovery ratios of the SLE patients with RP at 0 minute and 7 minute were lower than those without RP (p=0.0116 and 0.0136 respectively). The baseline perfusion of the cases decreased after treatment (p=0.033), but the recovery ratio of perfusion did not change significantly. The controls made no significant differences neither in baseline perfusion nor in recovery ratio of perfusion. There were differences between the SLE patients with RP and those without RP in peripheral perfusion. QW could reduce the perfusion of the SLE patients with RP, but it could not affect the recovery ratio of perfusion.
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