| Summary: | 碩士 === 國立臺灣大學 === 公共衛生學系 === 85 === Pulmonary tuberculosis and lung cancer are important
problems of public health in Taiwan. Pulmonary tuberculosis is
curable, but mortality of lung cancer is high. If pulmonary
tuberculosis is the risk factor of lung cancer, control of
pulmonary tuberculosis may decrease the incidence of lung
cancer. The frequencies of micronucleus formation of
peripheral lymphocytes were used as indicators of genetic damage
to explore the difference between patients of pulmonary
tuberculosis and control, and the change after antituberculosis
medication. Forty-three cases of newly diagnosed pulmonary
tuberculosis and sixty-four controls were recruited.
Cytokinesis-blocked micronucleus--ARA-c (CBMNA) were assayed.
The significant results are:1)the frequencies of micronucleus
formation have a 1.014 time increase with one-year increment of
age.2)the frequencies of micronucleus formation of cases were
1.56 times of control after adjusting the effects of age, sex,
smoking and drinking .3)the frequencies of micronucleus
formation after medication of antituberculosis drugs for two
months have a 0.704 time of premedication. The results
suggested genetic damages were found in pulmonary tuberculosis
patients, and medication of antituberculosis drugs might
decrease this effect. The mechanism needs further investigation.
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