| Summary: | 碩士 === 國立臺灣大學 === 毒理學研究所 === 85 === The tremogenic mycotoxin, territrem A (TRA) is a
secondary metabolite of Aspergillus terreus 23-1, which was
isolated from the CHCl3 extract of rice culture. In liver
microsome from male Wistar rat, TRA transformed into two
products, MA1 and MA2 in the presence of NADPH. But, in
liver microsome from female Wistar rat, TRA transformed
into only one product, designed as MA1. The sex difference
was observed in the formation of MA1 and MA2 by the
hepatic microsome isolated from Wistar rat. Castrated male
Wistar rat and ovarectomized female Wistar rat decreased
MA1 produced and then administration of estradiol recovered
MA1 product. MA2 can not found in the castrated male
Wistar rat and MA2 was produced in administration of
testosterone to castrated male Wistar rat and ovarectomized
female Wistar rat. From above studies suggested that
testosterone and estradiol were involved in the MA1
formation and MA1 to MA2 was testosterone dependent. Both
steps of reactions were enhanced by pretreatment of Wistar
rat with phenobarbital.
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