Study on relationship with sex hormone and metabolism of territrem B by liver microsome from wistar rat
碩士 === 國立臺灣大學 === 毒理學研究所 === 85 === Territrem B (TRB), a fungal metabolite isolated from Aspergillus terreus 23-1, is a tremogenic mycotoxin which does not contain nitrogen.By treatment with phenobarbital, TRB metabolism in liver microsomes from Wistar ra...
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ndltd-TW-085NTU002290062016-07-01T04:15:36Z http://ndltd.ncl.edu.tw/handle/56261030285621431900 Study on relationship with sex hormone and metabolism of territrem B by liver microsome from wistar rat 土震素B於大鼠肝臟微粒體的代謝與性荷爾蒙關係之探討 Jeng, Yea-Jen 鄭雅禎 碩士 國立臺灣大學 毒理學研究所 85 Territrem B (TRB), a fungal metabolite isolated from Aspergillus terreus 23-1, is a tremogenic mycotoxin which does not contain nitrogen.By treatment with phenobarbital, TRB metabolism in liver microsomes from Wistar rats can produce three metabolites : MB1, MB2 and MB4. In the metabolism of TRB to MB2, male rats are 30-fold higher than female rats. In the TRB metabolism of TRB to MB4, there are no significant sexual difference in male and female rats. In the castrated male rats, the production of MB2 decrease a lot but stilled higher than female rats. With testosterone implanting, the production of MB2 can recovery 80 %. With estradiol implanting, there are no siginficant recovery in the production of MB2. The results indicated that the production of MB2 is testosterone dependent. Peng Fu-Cho 彭福佐 --- 1997 學位論文 ; thesis 1 zh-TW |
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碩士 === 國立臺灣大學 === 毒理學研究所 === 85 === Territrem B (TRB), a fungal metabolite isolated from Aspergillus terreus 23-1,
is a tremogenic mycotoxin which does not contain nitrogen.By treatment with
phenobarbital, TRB metabolism in liver microsomes from Wistar rats can produce
three metabolites : MB1, MB2 and MB4. In the metabolism of TRB
to MB2, male rats
are 30-fold higher than female rats. In the TRB metabolism of TRB to MB4, there
are no significant sexual difference in male and female rats. In the castrated
male rats, the production of MB2 decrease a lot but stilled higher than female
rats. With testosterone implanting, the production of MB2 can recovery 80 %.
With estradiol implanting, there are no siginficant recovery in the production
of MB2. The results indicated that the production of MB2 is
testosterone dependent.
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author2 |
Peng Fu-Cho |
author_facet |
Peng Fu-Cho Jeng, Yea-Jen 鄭雅禎 |
author |
Jeng, Yea-Jen 鄭雅禎 |
spellingShingle |
Jeng, Yea-Jen 鄭雅禎 Study on relationship with sex hormone and metabolism of territrem B by liver microsome from wistar rat |
author_sort |
Jeng, Yea-Jen |
title |
Study on relationship with sex hormone and metabolism of territrem B by liver microsome from wistar rat |
title_short |
Study on relationship with sex hormone and metabolism of territrem B by liver microsome from wistar rat |
title_full |
Study on relationship with sex hormone and metabolism of territrem B by liver microsome from wistar rat |
title_fullStr |
Study on relationship with sex hormone and metabolism of territrem B by liver microsome from wistar rat |
title_full_unstemmed |
Study on relationship with sex hormone and metabolism of territrem B by liver microsome from wistar rat |
title_sort |
study on relationship with sex hormone and metabolism of territrem b by liver microsome from wistar rat |
publishDate |
1997 |
url |
http://ndltd.ncl.edu.tw/handle/56261030285621431900 |
work_keys_str_mv |
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