Study on relationship with sex hormone and metabolism of territrem B by liver microsome from wistar rat

碩士 === 國立臺灣大學 === 毒理學研究所 === 85 === Territrem B (TRB), a fungal metabolite isolated from Aspergillus terreus 23-1, is a tremogenic mycotoxin which does not contain nitrogen.By treatment with phenobarbital, TRB metabolism in liver microsomes from Wistar ra...

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Main Authors: Jeng, Yea-Jen, 鄭雅禎
Other Authors: Peng Fu-Cho
Format: Others
Language:zh-TW
Published: 1997
Online Access:http://ndltd.ncl.edu.tw/handle/56261030285621431900
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spelling ndltd-TW-085NTU002290062016-07-01T04:15:36Z http://ndltd.ncl.edu.tw/handle/56261030285621431900 Study on relationship with sex hormone and metabolism of territrem B by liver microsome from wistar rat 土震素B於大鼠肝臟微粒體的代謝與性荷爾蒙關係之探討 Jeng, Yea-Jen 鄭雅禎 碩士 國立臺灣大學 毒理學研究所 85 Territrem B (TRB), a fungal metabolite isolated from Aspergillus terreus 23-1, is a tremogenic mycotoxin which does not contain nitrogen.By treatment with phenobarbital, TRB metabolism in liver microsomes from Wistar rats can produce three metabolites : MB1, MB2 and MB4. In the metabolism of TRB to MB2, male rats are 30-fold higher than female rats. In the TRB metabolism of TRB to MB4, there are no significant sexual difference in male and female rats. In the castrated male rats, the production of MB2 decrease a lot but stilled higher than female rats. With testosterone implanting, the production of MB2 can recovery 80 %. With estradiol implanting, there are no siginficant recovery in the production of MB2. The results indicated that the production of MB2 is testosterone dependent. Peng Fu-Cho 彭福佐 --- 1997 學位論文 ; thesis 1 zh-TW
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language zh-TW
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description 碩士 === 國立臺灣大學 === 毒理學研究所 === 85 === Territrem B (TRB), a fungal metabolite isolated from Aspergillus terreus 23-1, is a tremogenic mycotoxin which does not contain nitrogen.By treatment with phenobarbital, TRB metabolism in liver microsomes from Wistar rats can produce three metabolites : MB1, MB2 and MB4. In the metabolism of TRB to MB2, male rats are 30-fold higher than female rats. In the TRB metabolism of TRB to MB4, there are no significant sexual difference in male and female rats. In the castrated male rats, the production of MB2 decrease a lot but stilled higher than female rats. With testosterone implanting, the production of MB2 can recovery 80 %. With estradiol implanting, there are no siginficant recovery in the production of MB2. The results indicated that the production of MB2 is testosterone dependent.
author2 Peng Fu-Cho
author_facet Peng Fu-Cho
Jeng, Yea-Jen
鄭雅禎
author Jeng, Yea-Jen
鄭雅禎
spellingShingle Jeng, Yea-Jen
鄭雅禎
Study on relationship with sex hormone and metabolism of territrem B by liver microsome from wistar rat
author_sort Jeng, Yea-Jen
title Study on relationship with sex hormone and metabolism of territrem B by liver microsome from wistar rat
title_short Study on relationship with sex hormone and metabolism of territrem B by liver microsome from wistar rat
title_full Study on relationship with sex hormone and metabolism of territrem B by liver microsome from wistar rat
title_fullStr Study on relationship with sex hormone and metabolism of territrem B by liver microsome from wistar rat
title_full_unstemmed Study on relationship with sex hormone and metabolism of territrem B by liver microsome from wistar rat
title_sort study on relationship with sex hormone and metabolism of territrem b by liver microsome from wistar rat
publishDate 1997
url http://ndltd.ncl.edu.tw/handle/56261030285621431900
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