| Summary: | 碩士 === 台北醫學院 === 藥學研究所 === 85 === The complexation of hydroxypropyl--cyclodextrin with bicyclic
compounds was studied. 5,8-Dihydroxy-1,4-naphthoquinone
derivatives(6+6 ring structure) and indole derivatives (6+5 ring
structure) were used as the model chemicals and the solubility
increment was employed as an indicator to monitor the
complexation progress. The solubility experiments revealed that
the position and 3-dimensional structure of the substituents
provided more impact on the solubility increment than the
polarity and chain length did. This result indicated that both
the position and 3-dimensional structure were the major
determinants affecting the complexation among the factors
studied. The control study with monocyclic compounds, using p-
hydroxybenzoic acid esters as the model chemicals, showed
opposite results. These results suggested that complexation of
hydroxypropyl--cyclodextrin with monocyclic compounds had a
different complexation mechanism with the bicyclic compounds.
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