| Summary: | 碩士 === 中國醫藥學院 === 中國醫藥研究所 === 86 === San-Huang-Hsieh-Hsin-Tang ( SHHHT ) , an traditional formula in China , consis
ts of three crude drugs : Rhei Rhizoma , Coptidis Rhizoma and Scutellariae Rad
ix., are widely used in the treatment of hypertension , anxiety , gastritis an
d several hemorrhage disorders. In this study , the pharmacokinetics and bioav
ail- ability ofthe SHHHT in rabbits were evaluated.A method for simultaneous d
etermination of the active constituents of the SHHHT, included baicalin , berb
erine and emodin in plasma by self-developed HPLC assay was described.After IV
administration of the SHHHT , ( contains baicalin 6.488 mg , berberine 5.506
mg and emodin 0.250 mg ) to the rabbits the plasma level-time courses of these
three compounds could be adequately described by an open two-compartment mode
l. The elimination half-lives of baicalin , berberine and emodin were 145 , 90
and 57 minutes respectively.The absolute bioavailability of these three compo
unds after oral administration of the SHHHT were 21.17 , 6.54 and 2.79 % for b
aicalin , berberine and emodin respectively. This result suggest that repeated
dose is necessary for SHHHT in clinical use.
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