Design and Synthesis of Pyrrolo[2,1-c][1,4]benzodiazepine Hybrid Agents
碩士 === 高雄醫學院 === 藥學研究所 === 86 === The pyrrolo[2,1-c][1,4]benzodiazepines (PBDs), a family of potent DNA-binding antitumor antibiotics , are produce by streptomyces species. These drugs react covalently with DNA to form an N2-guanine addu...
| Main Authors: | , |
|---|---|
| Other Authors: | |
| Format: | Others |
| Language: | zh-TW |
| Published: |
1998
|
| Online Access: | http://ndltd.ncl.edu.tw/handle/50956882661194243769 |
| id |
ndltd-TW-086KMC00551015 |
|---|---|
| record_format |
oai_dc |
| spelling |
ndltd-TW-086KMC005510152015-10-13T11:03:31Z http://ndltd.ncl.edu.tw/handle/50956882661194243769 Design and Synthesis of Pyrrolo[2,1-c][1,4]benzodiazepine Hybrid Agents 設計與合成比咯苯偶氮駢抗癌結合試劑 Hsu, Mei Hui 許美惠 碩士 高雄醫學院 藥學研究所 86 The pyrrolo[2,1-c][1,4]benzodiazepines (PBDs), a family of potent DNA-binding antitumor antibiotics , are produce by streptomyces species. These drugs react covalently with DNA to form an N2-guanine adduct that lies within the minor groove of DNA. Although they have the highly antitumor activity, they produce cardiotoxicity, which have precluded their continued clinical application. Therefore , we design and synthesis of hybrid agents base upon the PBD and indole carboxylate (IC). The hybrid agents were synthesized in eleven steps with 19~45% yields. The biological activities of these drugs are under investigation. Jeh-Jeng Wang 王志鉦 1998 學位論文 ; thesis 70 zh-TW |
| collection |
NDLTD |
| language |
zh-TW |
| format |
Others
|
| sources |
NDLTD |
| description |
碩士 === 高雄醫學院 === 藥學研究所 === 86 === The pyrrolo[2,1-c][1,4]benzodiazepines (PBDs), a family of
potent DNA-binding antitumor antibiotics , are produce by
streptomyces species. These drugs react covalently with DNA to
form an N2-guanine adduct that lies within the minor groove of
DNA. Although they have the highly antitumor activity, they
produce cardiotoxicity, which have precluded their continued
clinical application. Therefore , we design and synthesis of
hybrid agents base upon the PBD and indole carboxylate (IC). The
hybrid agents were synthesized in eleven steps with 19~45%
yields. The biological activities of these drugs are under
investigation.
|
| author2 |
Jeh-Jeng Wang |
| author_facet |
Jeh-Jeng Wang Hsu, Mei Hui 許美惠 |
| author |
Hsu, Mei Hui 許美惠 |
| spellingShingle |
Hsu, Mei Hui 許美惠 Design and Synthesis of Pyrrolo[2,1-c][1,4]benzodiazepine Hybrid Agents |
| author_sort |
Hsu, Mei Hui |
| title |
Design and Synthesis of Pyrrolo[2,1-c][1,4]benzodiazepine Hybrid Agents |
| title_short |
Design and Synthesis of Pyrrolo[2,1-c][1,4]benzodiazepine Hybrid Agents |
| title_full |
Design and Synthesis of Pyrrolo[2,1-c][1,4]benzodiazepine Hybrid Agents |
| title_fullStr |
Design and Synthesis of Pyrrolo[2,1-c][1,4]benzodiazepine Hybrid Agents |
| title_full_unstemmed |
Design and Synthesis of Pyrrolo[2,1-c][1,4]benzodiazepine Hybrid Agents |
| title_sort |
design and synthesis of pyrrolo[2,1-c][1,4]benzodiazepine hybrid agents |
| publishDate |
1998 |
| url |
http://ndltd.ncl.edu.tw/handle/50956882661194243769 |
| work_keys_str_mv |
AT hsumeihui designandsynthesisofpyrrolo21c14benzodiazepinehybridagents AT xǔměihuì designandsynthesisofpyrrolo21c14benzodiazepinehybridagents AT hsumeihui shèjìyǔhéchéngbǐgēběnǒudànpiánkàngáijiéhéshìjì AT xǔměihuì shèjìyǔhéchéngbǐgēběnǒudànpiánkàngáijiéhéshìjì |
| _version_ |
1716835683129098240 |