| Summary: | 碩士 === 國立成功大學 === 環境醫學研究所 === 86 === In Taiwan area, it thinks highly of occupational health
day by day. But , until now, it is not sure about the incidence
of occupational asthmaand there is no any study about this. The
relationship between occupational exposure and asthma is not
mere, it dependent on human sensitivity, exposure density,
exposure time, exposure channel...etc. Toluene diisocyanate
(TDI) is a highly reactive chemical used primarily in the
polyurethane industry. A number of important medical
consequences of TDI are neurological sequelae and pulmonary
toxicity. The diagnosis of TDI-induced asthma largely relies on
a comprehensive history and physical examination. In addition to
obtaining a detailed occupational history, specific laboratory
test can be helpful. This study was done in randomsampling at 7
plants that use TDI in the manufacture of polyurethane. The
assessment included a respiratory symptom questionnaire,
spirometry, Eotaxin. Recommendations include a stepwise approach
to diagnosing TDI-induced asthma in exposured workers and
differential diagnosis between TDI-induced asthma and common
asthma. 2 of these 58exposured workers(3.45%) had a significant
cross-shift decrease in forcedexpiratory volume in one second
and had sympyion of occupational asthma. 3 of 80 exposure
worker(3.75) had positive reaction in eotaxin, but normal in
pulmonary. In addition, assessment of exposure rectified by
expert system was used in this study It may utilized widely in
future epidemiological studies.
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