| Summary: | 碩士 === 台北醫學院 === 生藥學研究所 === 86 === Antacids are traditionally used for the treatment of peptic ulcer.In clinica
l, Tonic Chinese Medicinal prescriptions are the drugs for invigorating the sp
leen and stomach, usually used in the treatment of peptic ulcer by clinical Ch
inese Medical doctor. In this study, We have utilized artificial stomach of Fo
rdtran as a model system to quantitative analysis the water extracts of the in
vigorating the spleen and stomach in the extracts of Traditional Chinese Medic
ines, which include Si jun zi tang(四君子湯), Xiang sha liu jun zi tang(香砂六
君子湯), Shao-yao gan-cao tang(芍藥甘草湯), An zhong san(安中散), Ren shen yan
g rong tang(人參養榮湯), Shen ling bai-zhu san(參苓白朮散), Wu ji san(五積散),
and Si ni tang(四逆湯).The results are as following:1.The Antacid effect whic
h was tested by Acid Neutralizing Capacity(ANC):Colloidal aluminum phosphate(
磷酸鋁乳漿) (2.16*0.03)、Sodium bicarbonate(碳酸氫鈉)(1.83*0.03)、Shen ling ba
i-zhu san(參苓白朮散) (1.76*0.03)、Wu ji san(五積散)(1.72*0.09)、Ren shen yang
rong tang(人參養榮湯)(1.65*0.10)、Si ni tang(四逆湯) (1.60*0.05)、Xiang sha l
iu jun zi tang(香砂六君子湯) (1.58*0.06)、Si jun zi tang(四君子湯)(1.57*0.04)
、An zhong san(安中散)(1.53*0.03)、Shao-yao gan-cao tang(芍藥甘草湯)(1.53*0.02
)、water(水)(1.44*0.03).2.The duration of the acid neutralization(minutes): Co
lloidal aluminum phosphate(磷酸鋁乳漿)(172*3)、Xiang sha liu jun zi tang(香砂
六君子湯)(137*3)、An zhong san(安中散)(130*5)、Shen ling bai-zhu san(參苓白朮
散) (127*5)、Ren shen yang rong tang(人參養榮湯)(124*6)、Si jun zi tang(四君子
湯)(123*24)、Sodium bicarbonate(碳酸氫鈉)(121*14)、Wu ji san(五積散)(117*2)、S
i ni tang(四逆湯) (100*17)、Shao-yao gan-cao tang(芍藥甘草湯)(92*8)、water(水)
(87*6). The results of these studies indicate that antacid effects play an
important role in the gastric protective mechanisms of Traditional Chinese Med
icines in invigorating the spleen and stomach. One of the end point of hospice
movement is Taiwan in to create the Chinese model of hospice care for our peo
ple. The trial of TCDT was our preliminary effort for this end point.274 sequ
ential patients were included in this retrospective study. Questionnaire surve
y for autonomy demonstrated that 173 out of 274 terminal cancer patients (63.1
%) were willing to take TCDT. The remaining 101 (36.9%) patients who did not
take TDCT were assumed as the control group.The first five leading primary can
cers include Lung CA (25.5%), Liver CA (12.4%),Colorectal CA(10.9%),Stomach CA
(10.9%) and Cervical UT. CA (5.5%) comprised the major distribution of disease
entity. TCDT is prescribed according to the priority of their problem lists w
hich indicated pain (79.2%), weakness (69.0%), non-appetite(46.4%), fever(36.5
%), dyspnea (31.0%) and edema(31.0%). After admission, assessment and regular
medication of palliative care were performed for 1 week. TCDT followed with ta
ilored menu and served as dessert between meals for another 1 week. The result
s were evaluated by Verbal Numerical Scale method. Main components of menu wer
e composed of Tremella fuciformis, Paeonia Lactilora &Glycyrrhiza and other tr
aditional medicine profounded with vital substance. As the results of evaluati
on, 149(86.1%) patients shows their strong affinity to TCDT . Pain control was
significantly favored in the test group. Those having Glycyrrhiza -Paeonia so
up revealed pain relief(P<0.01). It is concluded that TCDT adjuvantly improves
quality of life of the terminal cancer patients(P<0.001). In terms of practic
al and clinical extension of TCDT , further prospective randomized study is ne
cessary to be organized.
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