| Summary: | 碩士 === 中原大學 === 醫學工程學系 === 87 === We investigated the effects of solvent evaporation rates on the encapsulation properties of PLLA and PDLLA microspheres,the followed encapsulation properties were studied:a)morphology of PLLA and PDLLA microspheres,b)encapsulation efficiencyand drug release of microspheres,c)effects of different solvent evaporation rates on the a) and b) iterms,and the crystal stracturechanges after hydration .When drug loading with lidocaine,porosity or pin hole surface of lidocaine/PLLAmicrospheres wereobserved but not in lidocaine/PDLLA microspheres.lidocaine/PLLA micrpspheres had higher drug encapsulation efficincyandhigher drug release rate than lidocaine/PDLLA microspheres.Atmosthere solvent evaporation (ASE) process during preparationthe microspheres showed higher particle sizes ,drug encapsulation efficiency and drug releae rates than they were prepared with reduced solvent evporation process (RSE). Further assaying PLLA microspheres prepared with ASE and RSE by DSC analysis ,hydration of PLLA microspheres of ASE would increase their crystal structure ,whereas it was not the case for the microspheresof RSE.
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