Associated Factor of Gout and The Risk for Hypertension

• Main Authors: Ya Wen Chang, 張雅雯
• Other Authors: Ying Chin Ko
• Format: Others
• Language: zh-TW
• Published: 1999
• Online Access: http://ndltd.ncl.edu.tw/handle/96937498982021938005

碩士 === 高雄醫學院 === 醫學研究所 === 87 === Hyperuricemia is a well known cause of gout, whose incidence and risk factors, such as obesity, hypertriglycerides, have been examined in several cross-sectional studies. In order to identify potential risks factors for the development of gout, we collected 48 cases of gout and 96 numbers of age- and sex-matched hospital controls in the nested case-control study. Cases of gout were identified from self-reporting of a doctor’s diagnosis based on clinical criteria. Baseline variables and biochemical data were examined as risk factors for the development of gout. Positive associations were found between gout and hyperuricemia (OR=4.64, 95% CI=1.83~11.67) and obesity (OR=3.66, 95% CI=1.01-13.3). Obesity and hyperuricemia are risk factors for the development of gout. Prevention of obesity and hyperuricemia may decrease the incidence of gout. We also want to examine the risk between gout and development of hypertension. Prospectively collected 82 gout cohort and 328 non-gout cohort from MJ Health Screening Center. Cases of gout were identified from self-reporting of a doctor’s diagnosis based on clinical criteria. The development of hypertension was determined by using published criteria. The risk for hypertension associated with gout was evaluated using cox proportional hazard model analysis. The incidence of hypertension was 7.89 and 4.53 per 100 person-years in the gout cohort and non-gout cohort. Prior gout was associated with the development of hypertension in univariate cox proportional hazard model ( RR=1.83, 95% CI=1.02-3.31). After adjusting for known hypertension risk factors in the multivariate cox proportional hazard model, the risk for hypertension was no longer significant (adjusted RR=1.29, 95% CI=0.70-2.40). Key words: gout, risk factor, hypertension