| Summary: | 碩士 === 中國文化大學 === 應用化學研究所 === 87 === Cancer has been the leading cause of death in Taiwan
Kinma area since 1984 1 .It is estimated that more than one
Fifth population in Taiwan Kinma area will die of cancer.Among
The causes of cancer death in Taiwan-Kinma area,lung cancer
Is the first leading death cause for female,the second leading
death cause for male,and the first for all In 1997,totally
5857 men and women died of lung cancer.obviously,lung cancer
is a major life-threatening health problem in Taiwan.
Two types of lung cancers make up 95% of all primary
lung neoplasms 2.They are small cell and non- small cell lung
carcinomas (SCLC and NSCLC).In Taiwan,SCLC omprises 12-15%
and NSCLC comprises 85-88%.NSCLC includes squamous cell
carcinomas,adenocarcinomas,and large cell carcinomas.SCLC
has better response rate to radiotherapy 80-90% and chemotherapy
90%,compared to 30-50% and 30-40%,respectively,in NSCLC.
However,the overall 5-year survival rates of SCLC and NSCLC
are less than10%,indicating the highly malignant nature of
lung cancers.In recent years,many oncogene and tumor suppressor
gene products,such as c-Myc3,4 and p53 5,were shown to be
modified be modified by O-linked N-acetylglucosamine (O-1cNAc).
In this study we will use molecular-pathological Methods
to investigate the functional and topological Regulation of
glycosylation-related genes in the biology and clinical
behavior of lung cancer,with emphasis on tumor invasion and
metastasis.Lung carcers have been shown to have a variety of
genetic abnormalities,which include deletions,amplifications
,activation of oncogenes (RAS,MYC,c-erbB-2,and BCL-2),and
inactivation of tumor suppressor genes(RB, P53, and P16 INK4A) 6
.The genetic abnormalities of lung cancers were vigorously
studied in recent years 7-10 however,recently no single genetic
marker is found to be sensitive and specific for efficient
diagnosis or therapy,indicating the multifactorial nature of
lung cancer tumo-rigenesis and the necessity of multivectorial
approach to lung cancer research.Molecular pathology is the
implementation of Molecular biology technology to pathological
sciences,combining the beauty of biochemical analysis and in
situ morphological observation. It is under rapid development
and be applied to almost any field of disease-oriented
biomedical research.In this study,we will pursue molecular
pathology approaches to the study of lung cancer as well as
the clinical pathological methodology of lung cancer research.
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