Effect of Chinese Herb (Yu-Hong-Gao) on Wound Healing of Deep Degree Burn in the Pig

• Main Authors: Yu-Hsin Chang, 張鈺鑫
• Other Authors: Yi-Chang Su
• Format: Others
• Language: zh-TW
• Published: 2000
• Online Access: http://ndltd.ncl.edu.tw/handle/06358520454757207144

碩士 === 中國醫藥學院 === 中國醫學研究所 === 88 === For assessing and comparing the effect of Yu-Hong-Gao(玉紅膏) and western medicine on wound healing of deep degree burn, a deep degree porcine burn model with repeated Latin-square design experiment method was used. Three burns were inflicted on both the flanks of the three pigs used in the present study. These burn wounds were divided into a control group, a western medicine group and a Chinese medicine group. Rate of reepithelialization was calculated at 7, 14, 21, 28 postburn days. Full thickness biopsies were taken at 3,7,14 and 28 postburn days for histopathological evaluation. As a result, the rate of reepithelialization of burn wounds which were treated with Yu-Hong-Gao was significantly increased as compared to that of the control group as well as the western medicine group at 21 postburn days. Comparing the Yu-Hong-Gao-treated burns and Silver Sulfadiazine-treated burns, we concluded that 1.) Both Yu-Hong-Gao and Silver Sulfadiazine could not improve the disintegration of the crust; 2.) Yu-Hong-Gao could promote the epidermal regeneration at late phase of wound healing; 3.) Yu-Hong-Gao could reduce the degree of fibroblast infiltration at late phase of wound healing; 4.) Yu-Hong-Gao could enhance the neovascularization of the wounded area during the process of wound healing; 5.) Yu-Hong-Gao could the reaction of inflammation.