| Summary: | 碩士 === 中國醫藥學院 === 醫學研究所 === 88 === Endometriosis, the chronic Gyn. disease with high relapse rate, presented the symptoms and signs of dysmenorrhea and
infertility. It was a benign disease but with cancer-like behavior including adhesions, invasion and metastasis. There were no causal therapy due to unclear pathogenesis till now.
Owing to estrogen-dependent characteristics, we choused estrogen receptor-a and -b isoforms and Cu,Zn-SOD expression in endometrium and endometrioma of reproductive women. Main outcome were measured with RT-PCR for ER-a and -b mRNA, IHC and Western blot for ER-a, -b and Cu,Zn-SOD protein expressions.
The results revealed that the ER-a mRNA and protein were lower in endometrioma than in endometrium, but ER-b mRNA and protein higher. ER--a and -b showed some expression in stroma of endometroma. Cu,Zn-SOD expressed markly in deep stroma of endometrioma. It might be concluded that ER-a might be damaged in ovarian endometrioma, and ER-b might fail to act with ER-a for normal estrogen dependency. This endocrinological status might lead to unigue estrogen-dependent growth, invasion and spreading of endometrioma, but need further studies to see the its real pathogenesis.
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