Studies on the Expression of Estrogen Receptor-αand —β and Superoxide Dismutase in Human Endometriosis

• Main Authors: Wu-Chou Lin, 林武周
• Other Authors: Horng-Der Tsai
• Format: Others
• Language: zh-TW
• Published: 2000
• Online Access: http://ndltd.ncl.edu.tw/handle/84279330974879809779

碩士 === 中國醫藥學院 === 醫學研究所 === 88 === Endometriosis, the chronic Gyn. disease with high relapse rate, presented the symptoms and signs of dysmenorrhea and infertility. It was a benign disease but with cancer-like behavior including adhesions, invasion and metastasis. There were no causal therapy due to unclear pathogenesis till now. Owing to estrogen-dependent characteristics, we choused estrogen receptor-a and -b isoforms and Cu,Zn-SOD expression in endometrium and endometrioma of reproductive women. Main outcome were measured with RT-PCR for ER-a and -b mRNA, IHC and Western blot for ER-a, -b and Cu,Zn-SOD protein expressions. The results revealed that the ER-a mRNA and protein were lower in endometrioma than in endometrium, but ER-b mRNA and protein higher. ER--a and -b showed some expression in stroma of endometroma. Cu,Zn-SOD expressed markly in deep stroma of endometrioma. It might be concluded that ER-a might be damaged in ovarian endometrioma, and ER-b might fail to act with ER-a for normal estrogen dependency. This endocrinological status might lead to unigue estrogen-dependent growth, invasion and spreading of endometrioma, but need further studies to see the its real pathogenesis.