Individual and Combined Antioxidant Effects of Seven Phenolic Agents in Human Erythrocyte Membrane Ghosts and Phosphatidylcholine Liposome Systems : the Importance of Partition Coefficient

• Main Authors: Kuei-Long Liao, 廖魁隆
• Other Authors: Mei-Chin Yin
• Format: Others
• Language: zh-TW
• Published: 2000
• Online Access: http://ndltd.ncl.edu.tw/handle/78130393979808486532

碩士 === 中山醫學院 === 營養科學研究所 === 88 === Abstract Antioxidant activities of seven phenolic agents against Fe2+-induced lipid oxidation were compared with -tocopherol, -carotene, vitamin C in human erythrocyte membrane ghosts and liposome systems. The antioxidant activity of five test flavonoids followed the order catechin > epicatechin > rutin > quercetin > myricetin in both systems (p<0.05), which was negatively correlated with their partition coefficients. The antioxidant interaction of these phenolic agents with -tocopherol, -carotene or vitamin C in inhibiting Fe2+-induced lipid oxidation was examined. Synergistic effects were present in the combinations of -tocopherol plus caffeic acid, catechin or epicatechin as well as all combinations of vitamin C plus phenolic antioxidants. Based on the stronger individual and combined effects present in caffeic acid, catechin and epicatechin, the application of these three phenolic agents with or without -tocopherol, -carotene, vitamin C may provide stronger protective benefits against lipid oxidation, which may be helpful for oxidation-related diseases prevention.