(A) The Preparation of Radiopharmaceutical for the Imaging of Cardiac β-Adrenoceptors (B) An Attempt to Synthesize Compound with 1,2,5-thiadiazole Partial Structure
碩士 === 中原大學 === 化學系 === 88 === ﹙A﹚The purpose of this project is to synthesize CYBL4E, an antagonist of cardiac β-adrenoceptor, which can be used as an imaging agent for heart. To synthesize CYBL4E, 2-amino-3- nitrophenol is used as the starting material. The starting material is first...
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ndltd-TW-088CYCU00650022015-10-13T11:50:52Z http://ndltd.ncl.edu.tw/handle/58958311834446193929 (A) The Preparation of Radiopharmaceutical for the Imaging of Cardiac β-Adrenoceptors (B) An Attempt to Synthesize Compound with 1,2,5-thiadiazole Partial Structure (A)心肌腎上腺素受體造影劑研製(B)含1,2,5-二部份構造化合物合成之嘗試 Tseng Wen Hsiung 曾文雄 碩士 中原大學 化學系 88 ﹙A﹚The purpose of this project is to synthesize CYBL4E, an antagonist of cardiac β-adrenoceptor, which can be used as an imaging agent for heart. To synthesize CYBL4E, 2-amino-3- nitrophenol is used as the starting material. The starting material is first transform to 1-(2-Amino-3-Nitrophenoxyl)-2’,3’- Epoxypropane .The substituent at 1-position is transformed to 3’-(Propargylamino)-2’- Propanol by the reaction of propargyl amine with the previous product. Reduction of the nitro group at 3-position converts the product in previous step into a 2,3-diamino compound. The reaction of phosgene with the 2,3-diamino compound gives 4-(3’-Propargylamino-2’-Hydroxypropoxyl)- Benzimidazol-2-one. The reaction of tributyltin chloride with the triple bond in the propargyl group converts this functional group to a tributylstannyl ethenyl group and give the precursor for imaging agent. ﹙B﹚ Urea , thionyl chloride , pyridine and α-Naphthoquinone in different conditions are allowed to react and Naphtho[2,3-c]- [1,2,5]thiadiazole-4,9-dione was obtained . Yang Chia Hsi 楊嘉喜 1999 學位論文 ; thesis 76 zh-TW |
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碩士 === 中原大學 === 化學系 === 88 === ﹙A﹚The purpose of this project is to synthesize CYBL4E, an antagonist of cardiac β-adrenoceptor, which can be used as an imaging agent for heart. To synthesize CYBL4E, 2-amino-3- nitrophenol is used as the starting material. The starting material is first transform to 1-(2-Amino-3-Nitrophenoxyl)-2’,3’- Epoxypropane .The substituent at 1-position is transformed to 3’-(Propargylamino)-2’- Propanol by the reaction of propargyl amine with the previous product. Reduction of the nitro group at 3-position converts the product in previous step into a 2,3-diamino compound. The reaction of phosgene with the 2,3-diamino compound gives 4-(3’-Propargylamino-2’-Hydroxypropoxyl)- Benzimidazol-2-one. The reaction of tributyltin chloride with the triple bond in the propargyl group converts this functional group to a tributylstannyl ethenyl group and give the precursor for imaging agent.
﹙B﹚ Urea , thionyl chloride , pyridine and α-Naphthoquinone in different conditions are allowed to react and Naphtho[2,3-c]- [1,2,5]thiadiazole-4,9-dione was obtained .
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Yang Chia Hsi |
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Yang Chia Hsi Tseng Wen Hsiung 曾文雄 |
author |
Tseng Wen Hsiung 曾文雄 |
spellingShingle |
Tseng Wen Hsiung 曾文雄 (A) The Preparation of Radiopharmaceutical for the Imaging of Cardiac β-Adrenoceptors (B) An Attempt to Synthesize Compound with 1,2,5-thiadiazole Partial Structure |
author_sort |
Tseng Wen Hsiung |
title |
(A) The Preparation of Radiopharmaceutical for the Imaging of Cardiac β-Adrenoceptors (B) An Attempt to Synthesize Compound with 1,2,5-thiadiazole Partial Structure |
title_short |
(A) The Preparation of Radiopharmaceutical for the Imaging of Cardiac β-Adrenoceptors (B) An Attempt to Synthesize Compound with 1,2,5-thiadiazole Partial Structure |
title_full |
(A) The Preparation of Radiopharmaceutical for the Imaging of Cardiac β-Adrenoceptors (B) An Attempt to Synthesize Compound with 1,2,5-thiadiazole Partial Structure |
title_fullStr |
(A) The Preparation of Radiopharmaceutical for the Imaging of Cardiac β-Adrenoceptors (B) An Attempt to Synthesize Compound with 1,2,5-thiadiazole Partial Structure |
title_full_unstemmed |
(A) The Preparation of Radiopharmaceutical for the Imaging of Cardiac β-Adrenoceptors (B) An Attempt to Synthesize Compound with 1,2,5-thiadiazole Partial Structure |
title_sort |
(a) the preparation of radiopharmaceutical for the imaging of cardiac β-adrenoceptors (b) an attempt to synthesize compound with 1,2,5-thiadiazole partial structure |
publishDate |
1999 |
url |
http://ndltd.ncl.edu.tw/handle/58958311834446193929 |
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