Study and Synthesis of Melanin Biosynthesis Inhibitor

• Main Authors: Wen-Ye Huang, 黃文毅
• Other Authors: Ching-Yuh Chen
• Format: Others
• Language: zh-TW
• Published: 2000
• Online Access: http://ndltd.ncl.edu.tw/handle/31047960746725822293

碩士 === 朝陽大學 === 應用化學系碩士班 === 88 === Sunburn causes the darkening of skin. It is caused by the increase in biosynthesis of melanin. Although melanin protect our skin from the damage of UV light, too much melanin will cause the cosmic problems. In 1995, a melanin biosynthesis inhibitor , (5aR*,6R*,9R*,9aS*)-4-cinnamoyl-3,6-dihydroxy-1-methoxy-6-methyl-9-(1-methylethyl)-5a,6,7,8,9,9a-hexahydrodibenzofuran 9 (cinnamoyl-hexahydro dibenzofuran derivative 9), was isolated from Lindera umbellata.It is used as our "Lead". We would like to synthesize the "Lead" compound-hexahydrodibenzo- -furan as well as a serious of effective compounds against the biosynthesis of melanin. One-electron oxidative coupling was applied with chalcone 10 and monoterpene 11 to get the final product.