| Summary: | 碩士 === 高雄醫學大學 === 藥學研究所 === 88 === Nine known compounds, β-sitosterol (2), justicidin E (3), justicidin D（neojusticin A）(4), taiwan E methyl ether (5), justicidin A (6), justicidin C（neojusticin B）(7), chinensinaphthol methyl ether (8), secoisolariciresinol dimethyl ether (9), and stigmasteryl-3-O-β-D-glucoside (10), as well as two new compounds, 3,4;3'',4''-bis-methylenedioxy-benzophenone (1) and procumbenoside A (11) have been isolated from the whole plant of Justicia procumbens L. (Acanthaceae). Compounds 4-8, cilinaphthol A (12), heliobuphthalmin (13) and chinensinaphthol (14) isolated from the other species of Justicia, were screened for anti-inflammatory activity. The results indicated that most of lignans didn''t show significant inhibitory effects on activation of mast cells, neutrophils, and RAW 264.7 cells stimulated by various inducers. Compound 5 and 12 showed significant inhibitory effects on TNF-α formation from N9 cells stimulated with LPS/IFN-γ. The present study suggested that the inhibition of TNF-αformation by 5 and 12 in microglial cells might be valuable in the therapeutic treatment or prevention of certain central as well as peripheral disease associated with increased TNF-α production.
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