Studies on the Cyclization Reactions of Diarylcarbazides with Various Aromatic Aldehydes and Ketones

• Main Authors: Hsieh Chin Sheng, 謝金生
• Other Authors: Yeh M. Y.
• Format: Others
• Language: zh-TW
• Published: 2000
• Online Access: http://ndltd.ncl.edu.tw/handle/06048575645179493496

碩士 === 國立成功大學 === 化學系 === 88 === In present study, 1,4-diarylcarbazides and 2,4-diarylcarbazides have been synthesized by using α-chloroformylarylhydrazine hydrochloride as a starting material. The cyclization reactions of both carbazides with aldehydes and ketones have also been investigated. There are four major parts in this research summarized as follows: 1. 1,4-Diarylcarbazides can react with ketones to generate 1,2,4-triazolidin-3-one. 2. In acidic condition, 1,4-diarylcabazides can react with 2,3-butanedione to produce 2-aryl-4-phenylamino-4,5-dihydro-2H- 1,2,4-triazin-3-one and the optimal reaction condition has been found. 3. Studies on synthetic reactions of 2,4-diarylcarbazides are presented in details. 4. 2,4-Diarylcarbazides,obtained from the above reactions,can react with aromatic either aldehydes or ketones to produce 1,2,4,5-tetrazin-3-ones which are rarely reported in literature. We hope that,through these studies,the special use of diarylcadazides in organic synthesis can be developed.