Chemical Constituents and Cytotoxicity of Soft Corals Sarcophyton crassocaule, Sarcophyton elegans and Sarcophyton trocheliophorum

碩士 === 國立中山大學 === 海洋資源學系研究所 === 88 === Chromatographic purification of a methylene chloride extract of Formosan soft coral Sarcophyton crassocaule (collected in Green island) led to the isolation of two new (1S*, 3R*, 4R*, 7E, 11E, 14R*)-3, 4-epoxycembra-7, 11, 15-trien-1, 14-olide (1) and (1R*, 3E,...

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Main Authors: Sheng-Ge Jung, 鍾勝格
Other Authors: 杜昌益
Format: Others
Language:zh-TW
Published: 1999
Online Access:http://ndltd.ncl.edu.tw/handle/06140526293620649870
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spelling ndltd-TW-088NSYS52770012016-07-08T04:22:57Z http://ndltd.ncl.edu.tw/handle/06140526293620649870 Chemical Constituents and Cytotoxicity of Soft Corals Sarcophyton crassocaule, Sarcophyton elegans and Sarcophyton trocheliophorum 綠島產肥厚肉質、美麗肉質及花環肉質軟珊瑚化學成分及癌細胞毒殺活性之研究 Sheng-Ge Jung 鍾勝格 碩士 國立中山大學 海洋資源學系研究所 88 Chromatographic purification of a methylene chloride extract of Formosan soft coral Sarcophyton crassocaule (collected in Green island) led to the isolation of two new (1S*, 3R*, 4R*, 7E, 11E, 14R*)-3, 4-epoxycembra-7, 11, 15-trien-1, 14-olide (1) and (1R*, 3E, 7E,11R*, 12S*, 14R*)-11, 12-epoxycembra-3, 7, 15-trien-1, 14-olide (2) isomeric diterpenoids , a known cyclic peroxide diterpenoid (1R*, 2S*, 3E, 7S*, 8R*, 11S*, 12Z)-8, 11-epidioxy-7-acetoxycembra-3, 12, 15-trien-1, 2-olide (3), as well as two known (24S)-24-methylcholestane-3b, 5a, 6b-triol (4) and 24x-methyl-cholestane -3b, 5a, 6b, 25-tetrol 25-monoacetate (5) steroids. Chromatographic fractionation of a methylene chloride extract of two Formosan soft corals Sarcophyton elegans (collected in Green island) led to the isolation of a known 24x-methylcholestane -3b, 5a, 6b, 25-tetrol 25-monoacetate (5) steroid, the methylene chloride extract of Sarcophyton trocheliophorum, on the other hand, afforded a known diterpenoid, (+)-isosarcophine (6). Purification of a methylene chloride extract of Octocorallia soft coral (unidentified) led to the isolation of two known steroids, cholesterol (7) and (22E, 24S)-24-methylcholesta-5, 22-dien-3b-ol (8). Compounds 1-7 exhibited cytotoxicity against P388 cancer cell line. Compounds 2 and 5 were active against HT-29 cancer cell line. 杜昌益 1999 學位論文 ; thesis 131 zh-TW
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language zh-TW
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description 碩士 === 國立中山大學 === 海洋資源學系研究所 === 88 === Chromatographic purification of a methylene chloride extract of Formosan soft coral Sarcophyton crassocaule (collected in Green island) led to the isolation of two new (1S*, 3R*, 4R*, 7E, 11E, 14R*)-3, 4-epoxycembra-7, 11, 15-trien-1, 14-olide (1) and (1R*, 3E, 7E,11R*, 12S*, 14R*)-11, 12-epoxycembra-3, 7, 15-trien-1, 14-olide (2) isomeric diterpenoids , a known cyclic peroxide diterpenoid (1R*, 2S*, 3E, 7S*, 8R*, 11S*, 12Z)-8, 11-epidioxy-7-acetoxycembra-3, 12, 15-trien-1, 2-olide (3), as well as two known (24S)-24-methylcholestane-3b, 5a, 6b-triol (4) and 24x-methyl-cholestane -3b, 5a, 6b, 25-tetrol 25-monoacetate (5) steroids. Chromatographic fractionation of a methylene chloride extract of two Formosan soft corals Sarcophyton elegans (collected in Green island) led to the isolation of a known 24x-methylcholestane -3b, 5a, 6b, 25-tetrol 25-monoacetate (5) steroid, the methylene chloride extract of Sarcophyton trocheliophorum, on the other hand, afforded a known diterpenoid, (+)-isosarcophine (6). Purification of a methylene chloride extract of Octocorallia soft coral (unidentified) led to the isolation of two known steroids, cholesterol (7) and (22E, 24S)-24-methylcholesta-5, 22-dien-3b-ol (8). Compounds 1-7 exhibited cytotoxicity against P388 cancer cell line. Compounds 2 and 5 were active against HT-29 cancer cell line.
author2 杜昌益
author_facet 杜昌益
Sheng-Ge Jung
鍾勝格
author Sheng-Ge Jung
鍾勝格
spellingShingle Sheng-Ge Jung
鍾勝格
Chemical Constituents and Cytotoxicity of Soft Corals Sarcophyton crassocaule, Sarcophyton elegans and Sarcophyton trocheliophorum
author_sort Sheng-Ge Jung
title Chemical Constituents and Cytotoxicity of Soft Corals Sarcophyton crassocaule, Sarcophyton elegans and Sarcophyton trocheliophorum
title_short Chemical Constituents and Cytotoxicity of Soft Corals Sarcophyton crassocaule, Sarcophyton elegans and Sarcophyton trocheliophorum
title_full Chemical Constituents and Cytotoxicity of Soft Corals Sarcophyton crassocaule, Sarcophyton elegans and Sarcophyton trocheliophorum
title_fullStr Chemical Constituents and Cytotoxicity of Soft Corals Sarcophyton crassocaule, Sarcophyton elegans and Sarcophyton trocheliophorum
title_full_unstemmed Chemical Constituents and Cytotoxicity of Soft Corals Sarcophyton crassocaule, Sarcophyton elegans and Sarcophyton trocheliophorum
title_sort chemical constituents and cytotoxicity of soft corals sarcophyton crassocaule, sarcophyton elegans and sarcophyton trocheliophorum
publishDate 1999
url http://ndltd.ncl.edu.tw/handle/06140526293620649870
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